| http://purl.uniprot.org/citations/38001239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/38001239 | http://www.w3.org/2000/01/rdf-schema#comment | "The source and roles of fibroblasts and T-cells during maladaptive remodeling and myocardial fibrosis in the setting of pulmonary arterial hypertension (PAH) have been long debated. We demonstrate, using single-cell mass cytometry, a subpopulation of endogenous human cardiac fibroblasts expressing increased levels of CD4, a helper T-cell marker, in addition to myofibroblast markers distributed in human fibrotic RV tissue, interstitial and perivascular lesions in SUGEN/Hypoxia (SuHx) rats, and fibroblasts labeled with pdgfrα CreERt2/+ in R26R-tdTomato mice. Recombinant IL-1β increases IL-1R, CCR2 receptor expression, modifies the secretome, and differentiates cardiac fibroblasts to form CD68-positive cell clusters. IL-1β also activates stemness markers, such as NANOG and SOX2, and genes involved in dedifferentiation, lymphoid cell function and metabolic reprogramming. IL-1β induction of lineage traced primary mouse cardiac fibroblasts causes these cells to lose their fibroblast identity and acquire an immune phenotype. Our results identify IL-1β induced immune-competency in human cardiac fibroblasts and suggest that fibroblast secretome modulation may constitute a therapeutic approach to PAH and other diseases typified by inflammation and fibrotic remodeling."xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.org/dc/terms/identifier | "doi:10.1038/s42003-023-05463-0"xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/author | "Zhao A."xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/author | "Gilbert R.J."xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/author | "Guirao-Abad J.P."xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/author | "Jeong J.Y."xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/author | "Sadayappan S."xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/author | "Rounds S."xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/author | "Dubielecka P.M."xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/author | "Kanisicak O."xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/author | "Siamwala J.H."xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/author | "Ivey M.J."xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/author | "Granston H."xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/author | "Pagano F.S."xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/name | "Commun Biol"xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/pages | "1200"xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/title | "IL-1beta-mediated adaptive reprogramming of endogenous human cardiac fibroblasts to cells with immune features during fibrotic remodeling."xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/38001239 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/38001239 |
| http://purl.uniprot.org/citations/38001239 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/38001239 |
| http://purl.uniprot.org/uniprot/#_A0A510GAG5-mappedCitation-38001239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38001239 |
| http://purl.uniprot.org/uniprot/#_A0AA51YZX7-mappedCitation-38001239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38001239 |