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http://purl.uniprot.org/citations/38006395http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/38006395http://www.w3.org/2000/01/rdf-schema#comment"

Introduction

Osteosarcoma is a malignant tumor, accounting for 20% of primary malignant bone tumors worldwide. However, the role of IBSP as a biomarker in osteosarcoma progression has not been studied yet.

Methods

85 cases of IBSP expression and clinical characteristics were obtained from TARGET database. Through the Kaplan-Meier curve, subgroup analysis, and univariate and multivariate Cox analysis, we further assessed the independent predictive capacity of IBSP expression for overall survival (OS) and relapse-free survival (RFS).

Results

The mRNA expression of IBSP was higher in osteosarcoma than normal tissue (P < 0.0001). IBSP expression grouped by vital status showed statistical differences (P = 0.042). The race (P = 0.0183), vital status (P = 0.0034), and sample type (P = 0.0020) showed significant differences. IBSP expression exhibited satisfied diagnostic ability for osteosarcoma. The univariate and multivariate analysis confirmed that IBSP expression was an independent risk factor for OS (HR = 3.425, 95% CI: 1.604-7.313, P = 0.002) and RFS (HR = 3.377, 95% CI: 1.775-6.424, P < 0.001) in osteosarcoma patients. High IBSP expression was significantly associated with poor OS and RFS (P < 0.0001). The higher IBSP expression was observed in osteosarcoma (P < 0.001), confirmed by the IHC staining. The CCK-8 and colony formation assay showed that IBSP knockdown inhibits cell proliferation while overexpression promotes cell proliferation (P < 0.05).

Conclusion

High expression of IBSP was associated with poor OS and RFS. IBSP could serve as a potential biomarker for osteosarcoma, which could aid in early detection and disease monitoring."xsd:string
http://purl.uniprot.org/citations/38006395http://purl.org/dc/terms/identifier"doi:10.18632/aging.205235"xsd:string
http://purl.uniprot.org/citations/38006395http://purl.uniprot.org/core/author"Chen B."xsd:string
http://purl.uniprot.org/citations/38006395http://purl.uniprot.org/core/author"Liu H."xsd:string
http://purl.uniprot.org/citations/38006395http://purl.uniprot.org/core/author"Liu Z."xsd:string
http://purl.uniprot.org/citations/38006395http://purl.uniprot.org/core/author"Ma Y."xsd:string
http://purl.uniprot.org/citations/38006395http://purl.uniprot.org/core/author"Wang X."xsd:string
http://purl.uniprot.org/citations/38006395http://purl.uniprot.org/core/author"Zhang C."xsd:string
http://purl.uniprot.org/citations/38006395http://purl.uniprot.org/core/author"Zhang B."xsd:string
http://purl.uniprot.org/citations/38006395http://purl.uniprot.org/core/author"Zhu Q."xsd:string
http://purl.uniprot.org/citations/38006395http://purl.uniprot.org/core/date"2023"xsd:gYear
http://purl.uniprot.org/citations/38006395http://purl.uniprot.org/core/name"Aging (Albany NY)"xsd:string
http://purl.uniprot.org/citations/38006395http://purl.uniprot.org/core/pages"28-42"xsd:string
http://purl.uniprot.org/citations/38006395http://purl.uniprot.org/core/title"High expression of integrin-binding sialoprotein (IBSP) is associated with poor prognosis of osteosarcoma."xsd:string
http://purl.uniprot.org/citations/38006395http://purl.uniprot.org/core/volume"16"xsd:string
http://purl.uniprot.org/citations/38006395http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/38006395
http://purl.uniprot.org/citations/38006395http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/38006395
http://purl.uniprot.org/uniprot/#_P21815-mappedCitation-38006395http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/38006395
http://purl.uniprot.org/uniprot/P21815http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/38006395