| http://purl.uniprot.org/citations/38012390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/38012390 | http://www.w3.org/2000/01/rdf-schema#comment | "Osteoarthritis (OA) is one of the most common joint diseases, there are no effective disease-modifying drugs, and the pathological mechanisms of OA need further investigation. Here, we show that H3K36 methylations were decreased in senescent chondrocytes and age-related osteoarthritic cartilage. Prrx1-Cre inducible H3.3K36M transgenic mice showed articular cartilage destruction and osteophyte formation. Conditional knockout Nsd1Prrx1-Cre mice, but not Nsd2Prrx1-Cre or Setd2Prrx1-Cre mice, replicated the phenotype of K36M/+; Prrx1-Cre mice. Immunostaining results showed decreased anabolic and increased catabolic activities in Nsd1Prrx1-Cre mice, along with decreased chondrogenic differentiation. Transcriptome and ChIP-seq data revealed that Osr2 was a key factor affected by Nsd1. Intra-articular delivery of Osr2 adenovirus effectively improved the homeostasis of articular cartilage in Nsd1Prrx1-Cre mice. In human osteoarthritic cartilages, both mRNA and protein levels of NSD1 and OSR2 were decreased. Our results indicate that NSD1-induced H3K36 methylations and OSR2 expression play important roles in articular cartilage homeostasis and OA. Targeting H3K36 methylation and OSR2 would be a novel strategy for OA treatment."xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41418-023-01244-8"xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://purl.uniprot.org/core/author | "Bi Q."xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://purl.uniprot.org/core/author | "Ma Y."xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://purl.uniprot.org/core/author | "Wen Y."xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://purl.uniprot.org/core/author | "Zou W."xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://purl.uniprot.org/core/author | "Zhuang L."xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://purl.uniprot.org/core/author | "Ge K."xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://purl.uniprot.org/core/author | "Suo J."xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://purl.uniprot.org/core/author | "Kong M."xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://purl.uniprot.org/core/author | "Shao R."xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://purl.uniprot.org/core/date | "2024"xsd:gYear |
| http://purl.uniprot.org/citations/38012390 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://purl.uniprot.org/core/pages | "106-118"xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://purl.uniprot.org/core/title | "H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasis."xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/38012390 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/38012390 |
| http://purl.uniprot.org/citations/38012390 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/38012390 |
| http://purl.uniprot.org/uniprot/#_E9QAE4-mappedCitation-38012390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38012390 |
| http://purl.uniprot.org/uniprot/#_A0A286YE36-mappedCitation-38012390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38012390 |
| http://purl.uniprot.org/uniprot/#_A0A410SEU7-mappedCitation-38012390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38012390 |