| http://purl.uniprot.org/citations/38030294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/38030294 | http://www.w3.org/2000/01/rdf-schema#comment | "Given the potential role of microRNA (miRNA) in the pathological process of ischemic heart disease, clinical patients with acute myocardial infarction (AMI) were recruited and serum miR-127-3p levels in the patients were tested. In vitro, the effects of miR-127-3p on cardiomyocyte apoptosis and inflammation induced by hypoxia and reoxygenation (H/R) were also elucidated in AC16 cells.Collection of serum samples from 113 AMI patients and 104 healthy controls was done. Human cardiomyocyte cell line AC16 was exposed to the H/R condition for the cell function experiments. qRT-PCR was applied for mRNA detection, and cell viability and apoptosis were evaluated. To assess inflammatory response, an enzyme-linked immunosorbent assay was carried out. For the target gene analysis, luciferase reporter assay was accomplished.MiR-127-3p was significantly reduced in the serum of AMI patients, which was negatively correlated with CDKN3 mRNA levels. Serum miR-127-3p was negatively correlated with Scr, cTnI, CK-MB, IL-6, and TNF-α. CDKN3 serves as a target gene of miR-127-3p, its mRNA levels were reduced by miR-127-3p overexpression. H/R treatment caused the suppression of cell viability and the promotion of cell apoptosis, which was changeover by miR-127-3p overexpression. Furthermore, MiR-127-3p overexpression inhibited cell inflammatory response. The rescue experiments revealed that CDKN3 overexpression canceled the protective influence of miR-127-3p against cardiomyocyte injury and inflammatory response.MiR-127-3p can alleviate AMI-induced cardiomyocyte apoptosis and cardiac dysfunction, which is related to its anti-inflammatory effect and its downstream CDKN3 gene."xsd:string |
| http://purl.uniprot.org/citations/38030294 | http://purl.org/dc/terms/identifier | "doi:10.1536/ihj.23-379"xsd:string |
| http://purl.uniprot.org/citations/38030294 | http://purl.uniprot.org/core/author | "Fang Z."xsd:string |
| http://purl.uniprot.org/citations/38030294 | http://purl.uniprot.org/core/author | "Zhu S."xsd:string |
| http://purl.uniprot.org/citations/38030294 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/38030294 | http://purl.uniprot.org/core/name | "Int Heart J"xsd:string |
| http://purl.uniprot.org/citations/38030294 | http://purl.uniprot.org/core/pages | "1133-1139"xsd:string |
| http://purl.uniprot.org/citations/38030294 | http://purl.uniprot.org/core/title | "MicroRNA-127-3p Inhibits Cardiomyocyte Inflammation and Apoptosis after Acute Myocardial Infarction via Targeting CDKN3."xsd:string |
| http://purl.uniprot.org/citations/38030294 | http://purl.uniprot.org/core/volume | "64"xsd:string |
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