| http://purl.uniprot.org/citations/38060647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/38060647 | http://www.w3.org/2000/01/rdf-schema#comment | "Kinetochores couple chromosomes to the mitotic spindle to segregate the genome during cell division. An error correction mechanism drives the turnover of kinetochore-microtubule attachments until biorientation is achieved. The structural basis for how kinetochore-mediated chromosome segregation is accomplished and regulated remains an outstanding question. In this work, we describe the cryo-electron microscopy structure of the budding yeast outer kinetochore Ndc80 and Dam1 ring complexes assembled onto microtubules. Complex assembly occurs through multiple interfaces, and a staple within Dam1 aids ring assembly. Perturbation of key interfaces suppresses yeast viability. Force-rupture assays indicated that this is a consequence of impaired kinetochore-microtubule attachment. The presence of error correction phosphorylation sites at Ndc80-Dam1 ring complex interfaces and the Dam1 staple explains how kinetochore-microtubule attachments are destabilized and reset."xsd:string |
| http://purl.uniprot.org/citations/38060647 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.adj8736"xsd:string |
| http://purl.uniprot.org/citations/38060647 | http://purl.uniprot.org/core/author | "Barford D."xsd:string |
| http://purl.uniprot.org/citations/38060647 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/38060647 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/38060647 | http://purl.uniprot.org/core/author | "Burt A."xsd:string |
| http://purl.uniprot.org/citations/38060647 | http://purl.uniprot.org/core/author | "Dendooven T."xsd:string |
| http://purl.uniprot.org/citations/38060647 | http://purl.uniprot.org/core/author | "Batters C."xsd:string |
| http://purl.uniprot.org/citations/38060647 | http://purl.uniprot.org/core/author | "Muir K.W."xsd:string |
| http://purl.uniprot.org/citations/38060647 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/38060647 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/38060647 | http://purl.uniprot.org/core/pages | "1184-1190"xsd:string |
| http://purl.uniprot.org/citations/38060647 | http://purl.uniprot.org/core/title | "Structural mechanism of outer kinetochore Dam1-Ndc80 complex assembly on microtubules."xsd:string |
| http://purl.uniprot.org/citations/38060647 | http://purl.uniprot.org/core/volume | "382"xsd:string |
| http://purl.uniprot.org/citations/38060647 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/38060647 |
| http://purl.uniprot.org/citations/38060647 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/38060647 |
| http://purl.uniprot.org/uniprot/#_P35734-mappedCitation-38060647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38060647 |
| http://purl.uniprot.org/uniprot/#_P33895-mappedCitation-38060647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38060647 |
| http://purl.uniprot.org/uniprot/#_Q12248-mappedCitation-38060647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38060647 |
| http://purl.uniprot.org/uniprot/#_P40460-mappedCitation-38060647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38060647 |
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| http://purl.uniprot.org/uniprot/#_P69851-mappedCitation-38060647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38060647 |
| http://purl.uniprot.org/uniprot/#_P69852-mappedCitation-38060647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38060647 |
| http://purl.uniprot.org/uniprot/#_Q03954-mappedCitation-38060647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38060647 |