| http://purl.uniprot.org/citations/38067135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/38067135 | http://www.w3.org/2000/01/rdf-schema#comment | "The complement system mediates diverse regulatory immunological functions. C5aR2, an enigmatic receptor for anaphylatoxin C5a, has been shown to modulate PRR-dependent pro-inflammatory cytokine secretion in human macrophages. However, the specific downstream targets and underlying molecular mechanisms are less clear. In this study, CRISPR-Cas9 was used to generate macrophage models lacking C5aR2, which were used to probe the role of C5aR2 in the context of PRR stimulation. cGAS and STING-induced IFN-β secretion was significantly increased in C5aR2 KO THP-1 cells and C5aR2-edited primary human monocyte-derived macrophages, and STING and IRF3 expression were increased, albeit not significantly, in C5aR2 KO cell lines implicating C5aR2 as a regulator of the IFN-β response to cGAS-STING pathway activation. Transcriptomic analysis by RNAseq revealed that nucleic acid sensing and antiviral signalling pathways were significantly up-regulated in C5aR2 KO THP-1 cells. Altogether, these data suggest a link between C5aR2 and nucleic acid sensing in human macrophages. With further characterisation, this relationship may yield therapeutic options in interferon-related pathologies."xsd:string |
| http://purl.uniprot.org/citations/38067135 | http://purl.org/dc/terms/identifier | "doi:10.3390/cells12232707"xsd:string |
| http://purl.uniprot.org/citations/38067135 | http://purl.uniprot.org/core/author | "Harris A."xsd:string |
| http://purl.uniprot.org/citations/38067135 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/38067135 | http://purl.uniprot.org/core/author | "Triantafilou K."xsd:string |
| http://purl.uniprot.org/citations/38067135 | http://purl.uniprot.org/core/author | "Durand M."xsd:string |
| http://purl.uniprot.org/citations/38067135 | http://purl.uniprot.org/core/author | "Nguyen V.D."xsd:string |
| http://purl.uniprot.org/citations/38067135 | http://purl.uniprot.org/core/author | "O'Neill L.A.J."xsd:string |
| http://purl.uniprot.org/citations/38067135 | http://purl.uniprot.org/core/author | "Booty L.M."xsd:string |
| http://purl.uniprot.org/citations/38067135 | http://purl.uniprot.org/core/author | "Wright O."xsd:string |
| http://purl.uniprot.org/citations/38067135 | http://purl.uniprot.org/core/author | "Nichols E.M."xsd:string |
| http://purl.uniprot.org/citations/38067135 | http://purl.uniprot.org/core/author | "Gormley D."xsd:string |
| http://purl.uniprot.org/citations/38067135 | http://purl.uniprot.org/core/author | "Jayyaratnam A."xsd:string |
| http://purl.uniprot.org/citations/38067135 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/38067135 | http://purl.uniprot.org/core/name | "Cells"xsd:string |
| http://purl.uniprot.org/citations/38067135 | http://purl.uniprot.org/core/pages | "2707"xsd:string |
| http://purl.uniprot.org/citations/38067135 | http://purl.uniprot.org/core/title | "C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages."xsd:string |
| http://purl.uniprot.org/citations/38067135 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/38067135 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/38067135 |
| http://purl.uniprot.org/citations/38067135 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/38067135 |
| http://purl.uniprot.org/uniprot/#_A0A2R3XZB7-mappedCitation-38067135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38067135 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GV38-mappedCitation-38067135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38067135 |
| http://purl.uniprot.org/uniprot/#_A0A494C0W5-mappedCitation-38067135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38067135 |
| http://purl.uniprot.org/uniprot/#_A0A3G1PSE3-mappedCitation-38067135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38067135 |