| http://purl.uniprot.org/citations/38069208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/38069208 | http://www.w3.org/2000/01/rdf-schema#comment | "Polycyclic aromatic hydrocarbon (PAH) pollutants and microbiome products converge on the aryl hydrocarbon receptor (AhR) to redirect selective rapid adherence of isolated bone marrow (BM) cells. In young adult mice, Cyp1b1-deficiency and AhR activation by PAH, particularly when prolonged by Cyp1a1 deletion, produce matching gene stimulations in these BM cells. Vascular expression of Cyp1b1 lowers reactive oxygen species (ROS), suppressing NF-κB/RelA signaling. PAH and allelic selectivity support a non-canonical AhR participation, possibly through RelA. Genes stimulated by Cyp1b1 deficiency were further resolved according to the effects of Cyp1b1 and Cyp1a1 dual deletions (DKO). The adherent BM cells show a cluster of novel stimulations, including select developmental markers; multiple re-purposed olfactory receptors (OLFR); and α-Defensin, a microbial disruptor. Each one connects to an enhanced specific expression of the catalytic RNA Pol2 A subunit, among 12 different subunits. Mesenchymal progenitor BMS2 cells retain these features. Cyp1b1-deficiency removes lymphocytes from adherent assemblies as BM-derived mesenchymal stromal cells (BM-MSC) expand. Cyp1b1 effects were cell-type specific. In vivo, BM-MSC Cyp1b1 expression mediated PAH suppression of lymphocyte progenitors. In vitro, OP9-MSC sustained these progenitors, while Csf1 induced monocyte progenitor expansion to macrophages. Targeted Cyp1b1 deletion (Cdh5-Cre; Cyp1b1fl/fl) established endothelium control of ROS that directs AhR-mediated suppression of B cell progenitors. Monocyte Cyp1b1 deletion (Lyz2-Cre; Cyp1b1fl/fl) selectively attenuated M1 polarization of expanded macrophages, but did not enhance effects on basal M2 polarization. Thus, specific sources of Cyp1b1 link to AhR and to an OLFR network to provide BM inflammatory modulation via diverse microbiome products."xsd:string |
| http://purl.uniprot.org/citations/38069208 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms242316884"xsd:string |
| http://purl.uniprot.org/citations/38069208 | http://purl.uniprot.org/core/author | "Alexander D.L."xsd:string |
| http://purl.uniprot.org/citations/38069208 | http://purl.uniprot.org/core/author | "Rondelli C.M."xsd:string |
| http://purl.uniprot.org/citations/38069208 | http://purl.uniprot.org/core/author | "Jefcoate C.R."xsd:string |
| http://purl.uniprot.org/citations/38069208 | http://purl.uniprot.org/core/author | "Song Y.S."xsd:string |
| http://purl.uniprot.org/citations/38069208 | http://purl.uniprot.org/core/author | "Sheibani N."xsd:string |
| http://purl.uniprot.org/citations/38069208 | http://purl.uniprot.org/core/author | "Larsen M.C."xsd:string |
| http://purl.uniprot.org/citations/38069208 | http://purl.uniprot.org/core/author | "Forsberg E.C."xsd:string |
| http://purl.uniprot.org/citations/38069208 | http://purl.uniprot.org/core/author | "Almeldin A."xsd:string |
| http://purl.uniprot.org/citations/38069208 | http://purl.uniprot.org/core/author | "N'Jai A."xsd:string |
| http://purl.uniprot.org/citations/38069208 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/38069208 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/38069208 | http://purl.uniprot.org/core/pages | "16884"xsd:string |
| http://purl.uniprot.org/citations/38069208 | http://purl.uniprot.org/core/title | "AhR and CYP1B1 Control Oxygen Effects on Bone Marrow Progenitor Cells: The Enrichment of Multiple Olfactory Receptors as Potential Microbiome Sensors."xsd:string |
| http://purl.uniprot.org/citations/38069208 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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