| http://purl.uniprot.org/citations/38070624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/38070624 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute cerebral ischemia triggers a profound inflammatory response. While macrophages polarized to an M2-like phenotype clear debris and facilitate tissue repair, aberrant or prolonged macrophage activation is counterproductive to recovery. The inhibitory immune checkpoint Programmed Cell Death Protein 1 (PD-1) is upregulated on macrophage precursors (monocytes) in the blood after acute cerebrovascular injury. To investigate the therapeutic potential of PD-1 activation, we immunophenotyped circulating monocytes from patients and found that PD-1 expression was upregulated in the acute period after stroke. Murine studies using a temporary middle cerebral artery (MCA) occlusion (MCAO) model showed that intraperitoneal administration of soluble Programmed Death Ligand-1 (sPD-L1) significantly decreased brain edema and improved overall survival. Mice receiving sPD-L1 also had higher performance scores short-term, and more closely resembled sham animals on assessments of long-term functional recovery. These clinical and radiographic benefits were abrogated in global and myeloid-specific PD-1 knockout animals, confirming PD-1+ monocytes as the therapeutic target of sPD-L1. Single-cell RNA sequencing revealed that treatment skewed monocyte maturation to a non-classical Ly6Clo, CD43hi, PD-L1+ phenotype. These data support peripheral activation of PD-1 on inflammatory monocytes as a therapeutic strategy to treat neuroinflammation after acute ischemic stroke."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbi.2023.12.007"xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Fan J."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Jain A."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Patel K."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Xu R."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Hou Z."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Kim J.E."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Tyler B."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Boussiotis V.A."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Shah P."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Robinson S."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Lim M."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Jackson C.M."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Levitan I."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Koehler R.C."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Lee R.P."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Pant A."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Gonzalez L.F."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Tamargo R.J."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Brem H."xsd:string |
| http://purl.uniprot.org/citations/38070624 | http://purl.uniprot.org/core/author | "Bibic A."xsd:string |