| http://purl.uniprot.org/citations/38078543 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/38078543 | http://www.w3.org/2000/01/rdf-schema#comment | "The kinase PAR-4/LKB1 is a major regulator of intestinal homeostasis, which prevents polyposis in humans. Moreover, its ectopic activation is sufficient to induce polarization and formation of microvilli-like structures in intestinal cell lines. Here, we use Caenorhabditis elegans to examine the role of PAR-4 during intestinal development in vivo. We show that it is not required to establish enterocyte polarity and plays only a minor role in brush border formation. By contrast, par-4 mutants display severe deformations of the intestinal lumen as well as supernumerary intestinal cells, thereby revealing a previously unappreciated function of PAR-4 in preventing intestinal hyperplasia. The presence of supernumerary enterocytes in par-4 mutants is not due to excessive cell proliferation, but rather to the abnormal expression of the intestinal cell fate factors end-1 and elt-2 outside the E lineage. Notably, par-4 mutants also display reduced expression of end-1 and elt-2 inside the E lineage. Our work thereby unveils an essential and dual role of PAR-4, which both restricts intestinal specification to the E lineage and ensures its robust differentiation."xsd:string |
| http://purl.uniprot.org/citations/38078543 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.202205"xsd:string |
| http://purl.uniprot.org/citations/38078543 | http://purl.uniprot.org/core/author | "Michaux G."xsd:string |
| http://purl.uniprot.org/citations/38078543 | http://purl.uniprot.org/core/author | "Pacquelet A."xsd:string |
| http://purl.uniprot.org/citations/38078543 | http://purl.uniprot.org/core/author | "Nicolle O."xsd:string |
| http://purl.uniprot.org/citations/38078543 | http://purl.uniprot.org/core/author | "Demouchy F."xsd:string |
| http://purl.uniprot.org/citations/38078543 | http://purl.uniprot.org/core/date | "2024"xsd:gYear |
| http://purl.uniprot.org/citations/38078543 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/38078543 | http://purl.uniprot.org/core/pages | "dev202205"xsd:string |
| http://purl.uniprot.org/citations/38078543 | http://purl.uniprot.org/core/title | "PAR-4/LKB1 prevents intestinal hyperplasia by restricting endoderm specification in Caenorhabditis elegans embryos."xsd:string |
| http://purl.uniprot.org/citations/38078543 | http://purl.uniprot.org/core/volume | "151"xsd:string |
| http://purl.uniprot.org/citations/38078543 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/38078543 |
| http://purl.uniprot.org/citations/38078543 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/38078543 |
| http://purl.uniprot.org/uniprot/#_Q9GN62-mappedCitation-38078543 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38078543 |
| http://purl.uniprot.org/uniprot/Q9GN62 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/38078543 |