Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/38082246http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/38082246http://www.w3.org/2000/01/rdf-schema#comment"

Objective

This study aimed to investigate the association between first-trimester Pregnancy-associated plasma protein A (PAPP-A) levels and subsequent gestational diabetes mellitus (GDM) development.

Method

The study was conducted on 5854 pregnant women who attended routine prenatal care. Maternal biomarkers, including PAPP-A and free beta hCG, were measured for all women in a referral laboratory and converted to MoM values. Pregnant women were divided into two groups, based on the serum concentration of PAPP-A, (PAPP-A > 0.4 (normal) and PAPP-A < 0.4 (low)). Data on the screening test for GDM and pregnancy outcomes were collected and analyzed with appropriate tests.

Result

Of the 5854 pregnant women, 889 (15.19%) developed GDM. The maternal PAPP-A MoM concentrations were significantly lower in GDM cases compared to controls. Indeed, gestational age at delivery and birth weight were significantly lower (p < 0.001) in PAPP-A MoM < 0.4, and the rate of intrauterine growth restriction (IUGR) was significantly higher (p < 0.001). ROC analysis revealed that the sensitivity and specificity of MoM concentration for predicting GDM were 53.3% and 51.9%, respectively.

Conclusion

Lower maternal PAPP-A in early pregnancy can lead to glucose intolerance and increase the risk of subsequent GDM development. In addition, decreased serum concentration of PAPP-A is significantly correlated to lower birth weight and IUGR."xsd:string
http://purl.uniprot.org/citations/38082246http://purl.org/dc/terms/identifier"doi:10.1186/s12884-023-06155-7"xsd:string
http://purl.uniprot.org/citations/38082246http://purl.uniprot.org/core/author"Borna S."xsd:string
http://purl.uniprot.org/citations/38082246http://purl.uniprot.org/core/author"Ghaemi M."xsd:string
http://purl.uniprot.org/citations/38082246http://purl.uniprot.org/core/author"Ashrafzadeh M."xsd:string
http://purl.uniprot.org/citations/38082246http://purl.uniprot.org/core/author"Eshraghi N."xsd:string
http://purl.uniprot.org/citations/38082246http://purl.uniprot.org/core/author"Hantoushzadeh S."xsd:string
http://purl.uniprot.org/citations/38082246http://purl.uniprot.org/core/author"Hivechi N."xsd:string
http://purl.uniprot.org/citations/38082246http://purl.uniprot.org/core/date"2023"xsd:gYear
http://purl.uniprot.org/citations/38082246http://purl.uniprot.org/core/name"BMC Pregnancy Childbirth"xsd:string
http://purl.uniprot.org/citations/38082246http://purl.uniprot.org/core/pages"847"xsd:string
http://purl.uniprot.org/citations/38082246http://purl.uniprot.org/core/title"Correlation between PAPP-A serum levels in the first trimester of pregnancy with the occurrence of gestational diabetes, a multicenter cohort study."xsd:string
http://purl.uniprot.org/citations/38082246http://purl.uniprot.org/core/volume"23"xsd:string
http://purl.uniprot.org/citations/38082246http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/38082246
http://purl.uniprot.org/citations/38082246http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/38082246
http://purl.uniprot.org/uniprot/#_B4DTA7-mappedCitation-38082246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/38082246
http://purl.uniprot.org/uniprot/#_B4DTA8-mappedCitation-38082246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/38082246
http://purl.uniprot.org/uniprot/#_Q13219-mappedCitation-38082246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/38082246
http://purl.uniprot.org/uniprot/#_Q5QFB7-mappedCitation-38082246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/38082246
http://purl.uniprot.org/uniprot/#_Q86YM8-mappedCitation-38082246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/38082246
http://purl.uniprot.org/uniprot/#_Q7Z613-mappedCitation-38082246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/38082246
http://purl.uniprot.org/uniprot/#_Q8IWT8-mappedCitation-38082246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/38082246
http://purl.uniprot.org/uniprot/Q86YM8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/38082246
http://purl.uniprot.org/uniprot/Q7Z613http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/38082246
▶