| http://purl.uniprot.org/citations/38123563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/38123563 | http://www.w3.org/2000/01/rdf-schema#comment | "TRIC-A and TRIC-B proteins form homotrimeric cation-permeable channels in the endoplasmic reticulum (ER) and nuclear membranes and are thought to contribute to counterionic flux coupled with store Ca2+ release in various cell types. Serious mutations in the TRIC-B (also referred to as TMEM38B) locus cause autosomal recessive osteogenesis imperfecta (OI), which is characterized by insufficient bone mineralization. We have reported that Tric-b-knockout mice can be used as an OI model; Tric-b deficiency deranges ER Ca2+ handling and thus reduces extracellular matrix (ECM) synthesis in osteoblasts, leading to poor mineralization. Here we report irregular cell death and insufficient ECM in long-bone growth plates from Tric-b-knockout embryos. In the knockout growth plate chondrocytes, excess pro-collagen fibers were occasionally accumulated in severely dilated ER elements. Of the major ER stress pathways, activated PERK/eIF2α (PKR-like ER kinase/ eukaryotic initiation factor 2α) signaling seemed to inordinately alter gene expression to induce apoptosis-related proteins including CHOP (CCAAT/enhancer binding protein homologous protein) and caspase 12 in the knockout chondrocytes. Ca2+ imaging detected aberrant Ca2+ handling in the knockout chondrocytes; ER Ca2+ release was impaired, while cytoplasmic Ca2+ level was elevated. Our observations suggest that Tric-b deficiency directs growth plate chondrocytes to pro-apoptotic states by compromising cellular Ca2+-handling and exacerbating ER stress response, leading to impaired ECM synthesis and accidental cell death."xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-023-06285-y"xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://purl.uniprot.org/core/author | "Nakajima N."xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://purl.uniprot.org/core/author | "Miyazaki Y."xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://purl.uniprot.org/core/author | "Okamoto N."xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://purl.uniprot.org/core/author | "Takeshima H."xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://purl.uniprot.org/core/author | "Kakizawa S."xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://purl.uniprot.org/core/author | "Kawabe T."xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://purl.uniprot.org/core/author | "Nishi M."xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://purl.uniprot.org/core/author | "Ichimura A."xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://purl.uniprot.org/core/author | "Nagatomo H."xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://purl.uniprot.org/core/author | "Komazaki S."xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://purl.uniprot.org/core/author | "Tomizawa M."xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://purl.uniprot.org/core/author | "Kim G.E."xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/38123563 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://purl.uniprot.org/core/pages | "848"xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://purl.uniprot.org/core/title | "Atypical cell death and insufficient matrix organization in long-bone growth plates from Tric-b-knockout mice."xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/38123563 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/38123563 |
| http://purl.uniprot.org/citations/38123563 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/38123563 |
| http://purl.uniprot.org/uniprot/#_Q9DAV9-mappedCitation-38123563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38123563 |
| http://purl.uniprot.org/uniprot/#_X1WI17-mappedCitation-38123563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38123563 |
| http://purl.uniprot.org/uniprot/X1WI17 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/38123563 |