| http://purl.uniprot.org/citations/38124753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/38124753 | http://www.w3.org/2000/01/rdf-schema#comment | "Toll-interacting protein (Tollip) is a negative regulator of the pro-inflammatory response to viruses, including influenza A virus (IAV). Genetic variation of Tollip has been associated with reduced airway epithelial Tollip expression and poor lung function in patients with asthma. Whether Tollip deficiency exaggerates type 2 inflammation (e.g., eosinophils) and viral infection in asthma remains unclear. We sought to address this critical, but unanswered question by using a Tollip deficient mouse asthma model with IAV infection. Further, we determined the underlying mechanisms by focusing on the role of the ATP/IL-33 signaling axis. Wild-type and Tollip KO mice were intranasally exposed to house dust mite (HDM) and IAV with or without inhibitors for IL-33 (i.e., soluble ST2, an IL-33 decoy receptor) and ATP signaling (i.e., an antagonist of the ATP receptor P2Y13). Tollip deficiency amplified airway type 2 inflammation (eosinophils, IL-5, IL-13 and mucins), and the release of ATP and IL-33. Blocking ATP receptor P2Y13 decreased IL-33 release during IAV infection in HDM-challenged Tollip KO mice. Furthermore, soluble ST2 attenuated airway eosinophilic inflammation in Tollip KO mice treated with HDM and IAV. HDM challenges decreased lung viral load in wild-type mice, but Tollip deficiency reduced the protective effects of HDM challenges on viral load. Our data suggests that during IAV infection, Tollip deficiency amplified type 2 inflammation and delayed viral clearance, in part by promoting ATP signaling and subsequent IL-33 release. Our findings may provide several therapeutic targets, including ATP and IL-33 signaling inhibition for attenuating excessive airway type 2 inflammation in human subjects with Tollip deficiency and IAV infection."xsd:string |
| http://purl.uniprot.org/citations/38124753 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2023.1304758"xsd:string |
| http://purl.uniprot.org/citations/38124753 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/38124753 | http://purl.uniprot.org/core/author | "Chu H.W."xsd:string |
| http://purl.uniprot.org/citations/38124753 | http://purl.uniprot.org/core/author | "Kraft M."xsd:string |
| http://purl.uniprot.org/citations/38124753 | http://purl.uniprot.org/core/author | "Numata M."xsd:string |
| http://purl.uniprot.org/citations/38124753 | http://purl.uniprot.org/core/author | "Nouri H.R."xsd:string |
| http://purl.uniprot.org/citations/38124753 | http://purl.uniprot.org/core/author | "Schaunaman N."xsd:string |
| http://purl.uniprot.org/citations/38124753 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/38124753 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/38124753 | http://purl.uniprot.org/core/pages | "1304758"xsd:string |
| http://purl.uniprot.org/citations/38124753 | http://purl.uniprot.org/core/title | "Tollip deficiency exaggerates airway type 2 inflammation in mice exposed to allergen and influenza A virus: role of the ATP/IL-33 signaling axis."xsd:string |
| http://purl.uniprot.org/citations/38124753 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/38124753 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/38124753 |
| http://purl.uniprot.org/citations/38124753 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/38124753 |
| http://purl.uniprot.org/uniprot/#_F2Z2Y8-mappedCitation-38124753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38124753 |
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| http://purl.uniprot.org/uniprot/#_E7EN89-mappedCitation-38124753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38124753 |
| http://purl.uniprot.org/uniprot/#_Q8BQL7-mappedCitation-38124753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38124753 |
| http://purl.uniprot.org/uniprot/#_Q6FIE9-mappedCitation-38124753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38124753 |
| http://purl.uniprot.org/uniprot/#_Q59FB9-mappedCitation-38124753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38124753 |