| http://purl.uniprot.org/citations/38135684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/38135684 | http://www.w3.org/2000/01/rdf-schema#comment | "Dysregulation of IL-17A is closely associated with airway inflammation and remodeling in severe asthma. However, the molecular mechanisms by which IL-17A is regulated remain unclear. Here we identify epithelial sirtuin 6 (SIRT6) as an epigenetic regulator that governs IL-17A pathogenicity in severe asthma. Mice with airway epithelial cell-specific deletion of Sirt6 are protected against allergen-induced airway inflammation and remodeling via inhibiting IL-17A-mediated inflammatory chemokines and mesenchymal reprogramming. Mechanistically, SIRT6 directly interacts with RORγt and mediates RORγt deacetylation at lysine 192 via its PPXY motifs. SIRT6 promotes RORγt recruitment to the IL-17A gene promoter and enhances its transcription. In severe asthma patients, high expression of SIRT6 positively correlates with airway remodeling and disease severity. SIRT6 inhibitor (OSS_128167) treatment significantly attenuates airway inflammation and remodeling in mice. Collectively, these results uncover a function for SIRT6 in regulating IL-17A pathogenicity in severe asthma, implicating SIRT6 as a potential therapeutic target for severe asthma."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-44179-x"xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Cai X."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Gao X."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Lai X."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Luo S."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Lin H."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Huang T."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Lv Y."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Luo C."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Zhong Y."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Shao Y."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Xiong Z."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Wen X."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Xiang Y."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Quan J."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Su G."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Zheng S.G."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/author | "Lai T."xsd:string |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/38135684 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |