| http://purl.uniprot.org/citations/38167790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/38167790 | http://www.w3.org/2000/01/rdf-schema#comment | "L-type voltage-gated calcium channels are involved in multiple physiological functions. Currently available antagonists do not discriminate between L-type channel isoforms. Importantly, no selective blocker is available to dissect the role of L-type isoforms Cav1.2 and Cav1.3 that are concomitantly co-expressed in the heart, neuroendocrine and neuronal cells. Here we show that calciseptine, a snake toxin purified from mamba venom, selectively blocks Cav1.2 -mediated L-type calcium currents (ICaL) at concentrations leaving Cav1.3-mediated ICaL unaffected in both native cardiac myocytes and HEK-293T cells expressing recombinant Cav1.2 and Cav1.3 channels. Functionally, calciseptine potently inhibits cardiac contraction without altering the pacemaker activity in sino-atrial node cells, underscoring differential roles of Cav1.2- and Cav1.3 in cardiac contractility and automaticity. In summary, calciseptine is a selective L-type Cav1.2 Ca2+ channel blocker and should be a valuable tool to dissect the role of these L-channel isoforms."xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-43502-w"xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/author | "Lazdunski M."xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/author | "Diochot S."xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/author | "Chemin J."xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/author | "Monteil A."xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/author | "Nargeot J."xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/author | "Soong T.W."xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/author | "Mangoni M.E."xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/author | "Torre E."xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/author | "Barrere C."xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/author | "Bidaud I."xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/author | "Barrere-Lemaire S."xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/author | "Mesirca P."xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/author | "Gallot L."xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/date | "2024"xsd:gYear |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/pages | "54"xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/title | "Selective blockade of Capisub>vpi/sub>1.2 (alpha1C) versus Capisub>vpi/sub>1.3 (alpha1D) L-type calcium channels by the black mamba toxin calciseptine."xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/38167790 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/38167790 |
| http://purl.uniprot.org/citations/38167790 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/38167790 |
| http://purl.uniprot.org/uniprot/#_A0A087WPP1-mappedCitation-38167790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38167790 |
| http://purl.uniprot.org/uniprot/#_A0A087WPZ8-mappedCitation-38167790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38167790 |