| http://purl.uniprot.org/citations/38207022 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/38207022 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumors develop strategies to evade immunity by suppressing antigen presentation. In this work, we show that prosaposin (pSAP) drives CD8 T cell-mediated tumor immunity and that its hyperglycosylation in tumor dendritic cells (DCs) leads to cancer immune escape. We found that lysosomal pSAP and its single-saposin cognates mediated disintegration of tumor cell-derived apoptotic bodies to facilitate presentation of membrane-associated antigen and T cell activation. In the tumor microenvironment, transforming growth factor-β (TGF-β) induced hyperglycosylation of pSAP and its subsequent secretion, which ultimately caused depletion of lysosomal saposins. pSAP hyperglycosylation was also observed in tumor-associated DCs from melanoma patients, and reconstitution with pSAP rescued activation of tumor-infiltrating T cells. Targeting DCs with recombinant pSAP triggered tumor protection and enhanced immune checkpoint therapy. Our studies demonstrate a critical function of pSAP in tumor immunity and may support its role in immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/38207022 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.adg1955"xsd:string |
| http://purl.uniprot.org/citations/38207022 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/38207022 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/38207022 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/38207022 | http://purl.uniprot.org/core/author | "Sharma P."xsd:string |
| http://purl.uniprot.org/citations/38207022 | http://purl.uniprot.org/core/author | "Teyton L."xsd:string |
| http://purl.uniprot.org/citations/38207022 | http://purl.uniprot.org/core/author | "Ly K."xsd:string |
| http://purl.uniprot.org/citations/38207022 | http://purl.uniprot.org/core/author | "Wan Q."xsd:string |
| http://purl.uniprot.org/citations/38207022 | http://purl.uniprot.org/core/author | "Lou M."xsd:string |
| http://purl.uniprot.org/citations/38207022 | http://purl.uniprot.org/core/author | "Winau F."xsd:string |
| http://purl.uniprot.org/citations/38207022 | http://purl.uniprot.org/core/author | "Kain L."xsd:string |
| http://purl.uniprot.org/citations/38207022 | http://purl.uniprot.org/core/date | "2024"xsd:gYear |
| http://purl.uniprot.org/citations/38207022 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/38207022 | http://purl.uniprot.org/core/pages | "190-200"xsd:string |
| http://purl.uniprot.org/citations/38207022 | http://purl.uniprot.org/core/title | "Hyperglycosylation of prosaposin in tumor dendritic cells drives immune escape."xsd:string |
| http://purl.uniprot.org/citations/38207022 | http://purl.uniprot.org/core/volume | "383"xsd:string |
| http://purl.uniprot.org/citations/38207022 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/38207022 |
| http://purl.uniprot.org/citations/38207022 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/38207022 |
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| http://purl.uniprot.org/uniprot/#_B4DEK5-mappedCitation-38207022 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38207022 |
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| http://purl.uniprot.org/uniprot/#_P07602-mappedCitation-38207022 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38207022 |
| http://purl.uniprot.org/uniprot/#_L8EA14-mappedCitation-38207022 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38207022 |