| http://purl.uniprot.org/citations/38227684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/38227684 | http://www.w3.org/2000/01/rdf-schema#comment | "Ubiquitination is a posttranslational modification that is crucial for the dynamic regulation of diverse signaling pathways. To enhance our understanding of ubiquitination-mediated signaling, we generated a new class of bispecific antibodies that combine recognition of ubiquitination substrates and specific polyubiquitin linkages. RIP1-K63 and RIP1-linear (Lin) linkage polyubiquitin bispecific antibodies detected linkage-specific ubiquitination of the proinflammatory kinase RIP1 in cells and in tissues and revealed RIP1 ubiquitination by immunofluorescence. Similarly, ubiquitination of the RIP1-related kinase RIP2 with K63 or linear linkages was specifically detected with the RIP2-K63 and RIP2-Lin bispecific antibodies, respectively. Furthermore, using the RIP2-K63 and RIP2-Lin bispecific antibodies, we found prominent K63-linked and linear RIP2 ubiquitination in samples from patients with ulcerative colitis and Crohn's disease. We also developed a bispecific antibody (K63-Lin) that simultaneously recognizes K63-linked and linear ubiquitination of components of various signaling pathways. Together, these bispecific antibodies represent a new class of reagents with the potential to be developed for the detection of inflammatory biomarkers."xsd:string |
| http://purl.uniprot.org/citations/38227684 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.abn1101"xsd:string |
| http://purl.uniprot.org/citations/38227684 | http://purl.uniprot.org/core/author | "Yu K."xsd:string |
| http://purl.uniprot.org/citations/38227684 | http://purl.uniprot.org/core/author | "Kist M."xsd:string |
| http://purl.uniprot.org/citations/38227684 | http://purl.uniprot.org/core/author | "Komuves L.G."xsd:string |
| http://purl.uniprot.org/citations/38227684 | http://purl.uniprot.org/core/author | "Vucic D."xsd:string |
| http://purl.uniprot.org/citations/38227684 | http://purl.uniprot.org/core/author | "Izrael-Tomasevic A."xsd:string |
| http://purl.uniprot.org/citations/38227684 | http://purl.uniprot.org/core/author | "Witt A."xsd:string |
| http://purl.uniprot.org/citations/38227684 | http://purl.uniprot.org/core/author | "Fedorova A.V."xsd:string |
| http://purl.uniprot.org/citations/38227684 | http://purl.uniprot.org/core/author | "Goncharov T."xsd:string |
| http://purl.uniprot.org/citations/38227684 | http://purl.uniprot.org/core/author | "Matsumoto M.L."xsd:string |
| http://purl.uniprot.org/citations/38227684 | http://purl.uniprot.org/core/author | "Keir M."xsd:string |
| http://purl.uniprot.org/citations/38227684 | http://purl.uniprot.org/core/author | "Castellanos E.R."xsd:string |
| http://purl.uniprot.org/citations/38227684 | http://purl.uniprot.org/core/date | "2024"xsd:gYear |
| http://purl.uniprot.org/citations/38227684 | http://purl.uniprot.org/core/name | "Sci Signal"xsd:string |
| http://purl.uniprot.org/citations/38227684 | http://purl.uniprot.org/core/pages | "eabn1101"xsd:string |
| http://purl.uniprot.org/citations/38227684 | http://purl.uniprot.org/core/title | "Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2."xsd:string |
| http://purl.uniprot.org/citations/38227684 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/38227684 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/38227684 |
| http://purl.uniprot.org/citations/38227684 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/38227684 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4Z8-mappedCitation-38227684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38227684 |
| http://purl.uniprot.org/uniprot/#_B3KU53-mappedCitation-38227684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38227684 |
| http://purl.uniprot.org/uniprot/#_B3KQM3-mappedCitation-38227684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38227684 |
| http://purl.uniprot.org/uniprot/#_E7ERW9-mappedCitation-38227684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38227684 |