| http://purl.uniprot.org/citations/38228402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/38228402 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in innate inflammatory processes. Here, we describe the discovery of two clinical candidate IRAK4 inhibitors, BAY1834845 (zabedosertib) and BAY1830839, starting from a high-throughput screening hit derived from Bayer's compound library. By exploiting binding site features distinct to IRAK4 using an in-house docking model, liabilities of the original hit could surprisingly be overcome to confer both candidates with a unique combination of good potency and selectivity. Favorable DMPK profiles and activity in animal inflammation models led to the selection of these two compounds for clinical development in patients."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.org/dc/terms/identifier | "doi:10.1021/acs.jmedchem.3c01714"xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Lange M."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Sutter A."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Schmidt N."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Eberspacher U."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Nubbemeyer R."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Peters M."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Steuber H."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Ring S."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Schafer M."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Siebeneicher H."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Zollner T.M."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Gunther J."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Denner K."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Bomer U."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Steinmeyer A."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Rausch A."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Wengner A.M."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Platzek J."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Himmel H."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Bothe U."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Guimond N."xsd:string |
| http://purl.uniprot.org/citations/38228402 | http://purl.uniprot.org/core/author | "Terebesi I."xsd:string |