DESCRIBE <http://purl.uniprot.org/citations/38246944>

Subject	Predicate	Object
http://purl.uniprot.org/citations/38246944	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/38246944	http://www.w3.org/2000/01/rdf-schema#comment	" Objectives Crohn's disease patients, who are prone to develop periodontal diseases, may carry genetic defects in their Th17 cytokine, human beta-defensin (hBD) 1-3, and salivary and scavenger agglutinin (SALSA) expressions. Biochemical composition of saliva reflects the oral consequences of systemic immune response modifications. Our aim was to evaluate the salivary Th17 cytokine, epithelial hBD 1-3, and SALSA levels in relation to Crohn's disease. Materials and methods This cross-sectional study included 42 Crohn's disease patients and 34 systemically healthy controls. Periodontal and dental indexes were measured, and stimulated saliva samples were collected. Salivary Th17 cytokine levels were analyzed by multiplex technique, and hBD 1-3 and SALSA levels by enzyme-linked immunosorbent assay. Results There were 19 gingivitis and 11 initial periodontitis patients in the Crohn's disease group, and 15 gingivitis and 4 initial periodontitis in the control group. In comparison to controls, higher salivary Th17 cytokine levels were observed in Crohn's disease patients. No statistical difference was observed between Crohn's disease and control groups in terms of their salivary hBD 1-3 and SALSA levels. Based on the regression analysis, there is no independent association between Crohn's disease and salivary Th17 cytokine levels. Conclusions Crohn's disease does not relate to salivary antimicrobial hBD 1-3 or SALSA levels. While Crohn's disease patients have higher salivary Th17 cytokine levels in comparison to systemically healthy controls, an independent association between Crohn's disease and Th17 cytokine profile is still missing. Clinical relevance Diminished Th17 cytokine response in Crohn's disease, which might be related to genetic susceptibility, can be also visualized in saliva."xsd:string
http://purl.uniprot.org/citations/38246944	http://purl.org/dc/terms/identifier	"doi:10.1007/s00784-024-05509-5"xsd:string
http://purl.uniprot.org/citations/38246944	http://purl.uniprot.org/core/author	"Loimaranta V."xsd:string
http://purl.uniprot.org/citations/38246944	http://purl.uniprot.org/core/author	"Rautava J."xsd:string
http://purl.uniprot.org/citations/38246944	http://purl.uniprot.org/core/author	"Gursoy U.K."xsd:string
http://purl.uniprot.org/citations/38246944	http://purl.uniprot.org/core/author	"Gursoy M."xsd:string
http://purl.uniprot.org/citations/38246944	http://purl.uniprot.org/core/date	"2024"xsd:gYear
http://purl.uniprot.org/citations/38246944	http://purl.uniprot.org/core/name	"Clin Oral Investig"xsd:string
http://purl.uniprot.org/citations/38246944	http://purl.uniprot.org/core/pages	"108"xsd:string
http://purl.uniprot.org/citations/38246944	http://purl.uniprot.org/core/title	"Salivary Th17 cytokine, human beta-defensin 1-3, and salivary scavenger and agglutinin levels in Crohn's disease."xsd:string
http://purl.uniprot.org/citations/38246944	http://purl.uniprot.org/core/volume	"28"xsd:string
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http://purl.uniprot.org/uniprot/#_A0A894JZ42-mappedCitation-38246944	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/38246944
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http://purl.uniprot.org/uniprot/#_O15263-mappedCitation-38246944	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/38246944
http://purl.uniprot.org/uniprot/#_L8E969-mappedCitation-38246944	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/38246944
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