| http://purl.uniprot.org/citations/38252822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/38252822 | http://www.w3.org/2000/01/rdf-schema#comment | "Long non-coding RNA (lncRNA) serves as a vital regulator of bone metabolism, but its role in pathologically overactive osteoclast differentiation remains elusive. Here, we identify lncRNA Dancr (Differentiation Antagonizing Non-protein Coding RNA) as a critical suppressor of osteoclastogenesis and bone resorption, which is down-regulated in response to estrogen deficiency. Global or osteoclast-specific Dancr Knockout mice display significant trabecular bone deterioration and enhanced osteoclast activity, but minimal alteration of bone formation. Moreover, the bone-targeted delivery of Dancr by Adeno-associated viral remarkably attenuates ovariectomy-induced osteopenia in mice. Mechanistically, Dancr establishes a direct interaction with Brahma-related gene 1 to prevent its binding and preserve H3K27me3 enrichment at the nuclear factor of activated T cells 1 and proliferator-activated receptor gamma coactivator 1-beta promoters, thereby maintaining appropriate expression of osteoclastic genes and metabolic programs during osteoclastogenesis. These results demonstrate that Dancr is a key molecule maintaining proper osteoclast differentiation and bone homeostasis under physiological conditions, and Dancr overexpression constitutes a potential strategy for treating osteoporosis."xsd:string |
| http://purl.uniprot.org/citations/38252822 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2313656121"xsd:string |
| http://purl.uniprot.org/citations/38252822 | http://purl.uniprot.org/core/author | "Lin T."xsd:string |
| http://purl.uniprot.org/citations/38252822 | http://purl.uniprot.org/core/author | "Meng Y."xsd:string |
| http://purl.uniprot.org/citations/38252822 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/38252822 | http://purl.uniprot.org/core/author | "Zhou X."xsd:string |
| http://purl.uniprot.org/citations/38252822 | http://purl.uniprot.org/core/author | "Yang F."xsd:string |
| http://purl.uniprot.org/citations/38252822 | http://purl.uniprot.org/core/author | "Zhang Z.'"xsd:string |
| http://purl.uniprot.org/citations/38252822 | http://purl.uniprot.org/core/author | "Yin H."xsd:string |
| http://purl.uniprot.org/citations/38252822 | http://purl.uniprot.org/core/author | "Tao Z."xsd:string |
| http://purl.uniprot.org/citations/38252822 | http://purl.uniprot.org/core/date | "2024"xsd:gYear |
| http://purl.uniprot.org/citations/38252822 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/38252822 | http://purl.uniprot.org/core/pages | "e2313656121"xsd:string |
| http://purl.uniprot.org/citations/38252822 | http://purl.uniprot.org/core/title | "Dancr-BRG1 regulates Nfatc1 transcription and Pgc1beta-dependent metabolic shifts in osteoclastogenesis."xsd:string |
| http://purl.uniprot.org/citations/38252822 | http://purl.uniprot.org/core/volume | "121"xsd:string |
| http://purl.uniprot.org/citations/38252822 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/38252822 |
| http://purl.uniprot.org/citations/38252822 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/38252822 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J170-mappedCitation-38252822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38252822 |
| http://purl.uniprot.org/uniprot/#_B2RWT8-mappedCitation-38252822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38252822 |
| http://purl.uniprot.org/uniprot/#_B5B2N2-mappedCitation-38252822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38252822 |
| http://purl.uniprot.org/uniprot/#_B5B2N4-mappedCitation-38252822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38252822 |
| http://purl.uniprot.org/uniprot/#_B5B2N5-mappedCitation-38252822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38252822 |
| http://purl.uniprot.org/uniprot/#_B5B2N7-mappedCitation-38252822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38252822 |
| http://purl.uniprot.org/uniprot/#_Q63928-mappedCitation-38252822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38252822 |