| http://purl.uniprot.org/citations/38291059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/38291059 | http://www.w3.org/2000/01/rdf-schema#comment | "Type 2 diabetes (T2D)-related fragility fractures represent an increasingly tough medical challenge, and the current treatment options are limited. Mechanical loading is essential for maintaining bone integrity, although bone mechano-responsiveness in T2D remains poorly characterized. Herein, we report that exogenous cyclic loading-induced improvements in bone architecture and strength are compromised in both genetically spontaneous and experimentally-induced T2D mice. T2D-induced reduction in bone mechano-responsiveness is directly associated with the weakened Ca2+ oscillatory dynamics of osteocytes, although not those of osteoblasts, which is dependent on PPARα-mediated specific reduction in osteocytic SERCA2 pump expression. Treatment with the SERCA2 agonist istaroxime was demonstrated to improve T2D bone mechano-responsiveness by rescuing osteocyte Ca2+ dynamics and the associated regulation of osteoblasts and osteoclasts. Moreover, T2D-induced deterioration of bone mechano-responsiveness is blunted in mice with osteocytic SERCA2 overexpression. Collectively, our study provides mechanistic insights into T2D-mediated deterioration of bone mechano-responsiveness and identifies a promising countermeasure against T2D-associated fragility fractures."xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-024-45023-6"xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/author | "Ding Y."xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/author | "Shen L."xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/author | "Tian Y."xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/author | "Yan Z."xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/author | "Luo W."xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/author | "Cai J."xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/author | "Hao X."xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/author | "Shao X."xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/author | "Jing D."xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/author | "Luo E."xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/author | "Luo P."xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/author | "Guo X.E."xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/date | "2024"xsd:gYear |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/pages | "890"xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/title | "Rescuing SERCA2 pump deficiency improves bone mechano-responsiveness in type 2 diabetes by shaping osteocyte calcium dynamics."xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/38291059 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/38291059 |
| http://purl.uniprot.org/citations/38291059 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/38291059 |
| http://purl.uniprot.org/uniprot/#_O55143-mappedCitation-38291059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/38291059 |