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http://purl.uniprot.org/citations/38309700http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/38309700http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

The acute respiratory syndrome, known as COVID-19, is characterised by high morbidity and increased mortality. Genetic factors may partially explain the differences in susceptibility to and severity of COVID-19.

Methods

We have analysed common functional polymorphisms within the OAS1 (rs4767027), TMPRSS6 (rs855791), DPP4 (rs3788979), and ZNF335 (rs3848719) genes in SARS-CoV-2 positive subjects (n = 521, different disease severity) and in population controls (n = 2,559 subjects, COVID-19 status unknown).

Results

Neither DPP4 nor ZNF335 were associated with disease susceptibility or severity in the Czech population in any of the models used for calculation. T allele carriers of the OAS1 polymorphism seem to be protective against symptomatic COVID-19 (p = 0.002 calculated for trend; asymptomatic, symptomatic, hospitalised). Similarly, within the TMPRSS6, minor TT homozygotes associated with lower plasma Fe concentrations were underrepresented in the overall patient group (p = 0.044; OR = 0.77, 95% CI: 0.59-0.99), and the difference was mainly driven by the severe COVID-19 subjects. In general, risky homozygotes of these two polymorphisms were less frequent than expected in the group of hospitalised COVID-19 survivors.

Conclusions

Common variants within OAS1 (rs4767027) and TMPRSS6 (rs855791) play some role in COVID-19 pathology in the Czech Caucasian population. Whether the depletion of minor allele carriers of these two variants is associated with increased COVID-19 mortality, needs to be analysed in an external confirmatory study."xsd:string
http://purl.uniprot.org/citations/38309700http://purl.org/dc/terms/identifier"doi:10.21101/cejph.a7906"xsd:string
http://purl.uniprot.org/citations/38309700http://purl.uniprot.org/core/author"Hubacek J.A."xsd:string
http://purl.uniprot.org/citations/38309700http://purl.uniprot.org/core/author"Adamkova V."xsd:string
http://purl.uniprot.org/citations/38309700http://purl.uniprot.org/core/author"Philipp T."xsd:string
http://purl.uniprot.org/citations/38309700http://purl.uniprot.org/core/author"Dusek L."xsd:string
http://purl.uniprot.org/citations/38309700http://purl.uniprot.org/core/author"Dlouha D."xsd:string
http://purl.uniprot.org/citations/38309700http://purl.uniprot.org/core/author"Majek O."xsd:string
http://purl.uniprot.org/citations/38309700http://purl.uniprot.org/core/date"2023"xsd:gYear
http://purl.uniprot.org/citations/38309700http://purl.uniprot.org/core/name"Cent Eur J Public Health"xsd:string
http://purl.uniprot.org/citations/38309700http://purl.uniprot.org/core/pages"235-239"xsd:string
http://purl.uniprot.org/citations/38309700http://purl.uniprot.org/core/title"Possible effect of OAS1 and TMPRSS6 but not DPP4 and ZNF335 polymorphisms on COVID-19 severity in the Czech population."xsd:string
http://purl.uniprot.org/citations/38309700http://purl.uniprot.org/core/volume"31"xsd:string
http://purl.uniprot.org/citations/38309700http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/38309700
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