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http://purl.uniprot.org/citations/3866244http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/3866244http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/3866244http://www.w3.org/2000/01/rdf-schema#comment"The organization and sequences of the human beta-chain T-cell receptor diversity, joining, and constant region segments are described. The beta chain of the human T-cell receptor, analogous to the mouse counterpart, consists of two distinct constant region genes approximately equal to 10 kilobases apart. The two constant region genes, C beta 1 and C beta 2, are very similar not only in sequence but also in genomic organization. The coding sequences of each of these C beta constant region genes are divided into four exons. The first two exons encode most of the extracellular constant domain. The third exon encodes a major part of the presumed transmembrane portion, and the last exon contains the cytoplasmic coding sequence as well as 3' untranslated sequences. Except for a stretch of approximately equal to 95 highly conserved nucleotides extending 3' of the first exon of the C region genes, little homology can be found between the intron sequences of C beta 1 and C beta 2. A small cluster of joining region (J beta) gene segments is located approximately equal to 5 kilobases upstream of each of these two constant regions. The first cluster, J beta 1, contains six functional J gene segments while the second, J beta 2, contains seven functional J gene segments. In addition, diversity region (D beta) gene segments are located approximately equal to 600 base pairs upstream of each J beta. Recombinational signals containing highly conserved heptamer and nonamer sequences separated by 12 or 23 bases are found adjacent to all of these D beta and J beta gene segments. These signal sequences are thought to be involved in the somatic recombination processes. These results indicate that what appears to be a gene duplication event giving rise to these two distinct regions must have arisen a long time ago in the evolution of this gene locus."xsd:string
http://purl.uniprot.org/citations/3866244http://purl.org/dc/terms/identifier"doi:10.1073/pnas.82.24.8624"xsd:string
http://purl.uniprot.org/citations/3866244http://purl.org/dc/terms/identifier"doi:10.1073/pnas.82.24.8624"xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/author"Mak T.W."xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/author"Mak T.W."xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/author"Chin B."xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/author"Chin B."xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/author"Yoshikai Y."xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/author"Yoshikai Y."xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/author"Toyonaga B."xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/author"Toyonaga B."xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/author"Vadasz V."xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/author"Vadasz V."xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/date"1985"xsd:gYear
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/date"1985"xsd:gYear
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/name"Proc. Natl. Acad. Sci. U.S.A."xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/name"Proc. Natl. Acad. Sci. U.S.A."xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/pages"8624-8628"xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/pages"8624-8628"xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/title"Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain."xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/title"Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain."xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/volume"82"xsd:string
http://purl.uniprot.org/citations/3866244http://purl.uniprot.org/core/volume"82"xsd:string
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