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| http://purl.uniprot.org/citations/4275392 | http://www.w3.org/2000/01/rdf-schema#comment | "The reason for the failure of early-stage mouse embryos to grow on glucose alone was investigated by measurement of glucose-6-phosphate, fructose-1,6-bisphosphate plus triose phosphates, citrate, and malate in individual embryos during starvation and refeeding with glucose or glucose plus pyruvate. The results indicate a block at the 6-phosphofructokinase (EC 2.7.1.11) step at early stages, which is later removed. Although there seems to be no early difficulty in phosphorylation of glucose, maximum glucose-6-phosphate levels (and probably fructose-6-phosphate levels) are much lower at early stages than at later stages. The increase in fructose-6-phosphate with age may be the major cause of the increase in 6-phosphofructokinase activity. Unusually high citrate levels at all ages may help to keep this enzyme strongly inhibited until the increase in fructose-6-phosphate occurs. The changes in metabolite levels also indicate an early defect in mobilization of glycogen and a probably less important defect in the citrate cycle."xsd:string |
| http://purl.uniprot.org/citations/4275392 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.71.4.1056"xsd:string |
| http://purl.uniprot.org/citations/4275392 | http://purl.uniprot.org/core/author | "Barbehenn E.K."xsd:string |
| http://purl.uniprot.org/citations/4275392 | http://purl.uniprot.org/core/author | "Lowry O.H."xsd:string |
| http://purl.uniprot.org/citations/4275392 | http://purl.uniprot.org/core/author | "Wales R.G."xsd:string |
| http://purl.uniprot.org/citations/4275392 | http://purl.uniprot.org/core/date | "1974"xsd:gYear |
| http://purl.uniprot.org/citations/4275392 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/4275392 | http://purl.uniprot.org/core/pages | "1056-1060"xsd:string |
| http://purl.uniprot.org/citations/4275392 | http://purl.uniprot.org/core/title | "The explanation for the blockade of glycolysis in early mouse embryos."xsd:string |
| http://purl.uniprot.org/citations/4275392 | http://purl.uniprot.org/core/volume | "71"xsd:string |
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