| http://purl.uniprot.org/citations/429297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/429297 | http://www.w3.org/2000/01/rdf-schema#comment | "The AUG-dependent formation of an 80 S ribosomal initiation complex was studied using purified rabbit reticulocyte initiation factors radiolabeled by reductive methylation. The radiolabeled initiation factors were as biologically active as untreated factors. Reaction mixtures containing a variety of components (AUG, GTP, Met-tRNAf, initiation factors, and 40 S and 60 S ribosomal subunits) were incubated at 30 degrees C and then analyzed on linear sucrose gradients for the formation of ribosomal complexes. The results show that both eukaryotic initiation factor (eIF)-3 and the ternary complex (eIF-2.GTP.Met-tRNAf) bind independently to the 40 S subunit and each of these components enhances the binding of the other. All of the polypeptides of eIF-2 and eIF-3 participate in this binding. Formation of an 80 S ribosomal complex requires eIF-5 and 60 S subunits in a reaction that is stimulated by eIF-4C. Both eIF-2 and eIF-3 are released from the 40 S preinitiation complex during formation of the 80 S initiation complex. Release of eIF-2 and eIF-3 does not occur and 80 S ribosomal complexes are not formed if GTP is replaced by a nonhydrolyzable analog such as guanosine 5'-O3-(1,2-mu-imido)triphosphate. Despite a variety of attempts, it has not yet been possible to demonstrate binding of eIF-4C, eIF-4D, or eIF-5 to either 40 S or 80 S ribosomal complexes."xsd:string |
| http://purl.uniprot.org/citations/429297 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(17)30251-x"xsd:string |
| http://purl.uniprot.org/citations/429297 | http://purl.uniprot.org/core/author | "Merrick W.C."xsd:string |
| http://purl.uniprot.org/citations/429297 | http://purl.uniprot.org/core/author | "Safer B."xsd:string |
| http://purl.uniprot.org/citations/429297 | http://purl.uniprot.org/core/author | "Peterson D.T."xsd:string |
| http://purl.uniprot.org/citations/429297 | http://purl.uniprot.org/core/date | "1979"xsd:gYear |
| http://purl.uniprot.org/citations/429297 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/429297 | http://purl.uniprot.org/core/pages | "2509-2516"xsd:string |
| http://purl.uniprot.org/citations/429297 | http://purl.uniprot.org/core/title | "Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation."xsd:string |
| http://purl.uniprot.org/citations/429297 | http://purl.uniprot.org/core/volume | "254"xsd:string |
| http://purl.uniprot.org/citations/429297 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/429297 |
| http://purl.uniprot.org/citations/429297 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/429297 |
| http://purl.uniprot.org/uniprot/#_Q14152-mappedCitation-429297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/429297 |
| http://purl.uniprot.org/uniprot/#_Q14240-mappedCitation-429297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/429297 |
| http://purl.uniprot.org/uniprot/#_Q15056-mappedCitation-429297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/429297 |
| http://purl.uniprot.org/uniprot/#_P20042-mappedCitation-429297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/429297 |
| http://purl.uniprot.org/uniprot/#_P39019-mappedCitation-429297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/429297 |
| http://purl.uniprot.org/uniprot/#_P42677-mappedCitation-429297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/429297 |
| http://purl.uniprot.org/uniprot/#_P62701-mappedCitation-429297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/429297 |
| http://purl.uniprot.org/uniprot/#_P62753-mappedCitation-429297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/429297 |
| http://purl.uniprot.org/uniprot/#_P62841-mappedCitation-429297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/429297 |
| http://purl.uniprot.org/uniprot/#_P62847-mappedCitation-429297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/429297 |
| http://purl.uniprot.org/uniprot/#_P62851-mappedCitation-429297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/429297 |
| http://purl.uniprot.org/uniprot/#_P62854-mappedCitation-429297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/429297 |