| http://purl.uniprot.org/citations/4375977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/4375977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/4375977 | http://www.w3.org/2000/01/rdf-schema#comment | "An adrenocorticotrophic hormone (ACTH) was isolated from extracts of the pars distalis of the pituitary of the dogfish Squalus acanthias by gel filtration and ion-exchange chromatography. It had 15% of the potency of human ACTH in promoting cortico-steroidogenesis in isolated rat adrenal cells. Sequence analysis revealed it to be a nonatria-contapeptide with the following primary structure: Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Met-Gly-Arg-Lys-Arg-Arg-Pro-Ile-Lys-Val-Tyr-Pro-Asn-Ser-Phe-Glu-Asp-Glu-Ser-Val-Glu-Asn-Met-Gly-Pro-Glu-Leu. The N-terminal tridecapeptide sequence was identical with the proposed structure of dogfish alpha-melanocyte-stimulating hormone (alpha-MSH). On comparison with human ACTH eleven amino acid differences were seen, nine of which are in the 20-39 region of the molecule which is not essential for the steroidogenic activity of ACTH. A peptide identical with the 18-39 portion of this new ACTH was similarly isolated from the neurointermediate lobe of the pituitary where considerable amounts of dogfish alpha-MSH were found. This supported our view that ACTH as well as having a distinct biological role of its own is also the precursor of alpha-MSH."xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj1410427"xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj1410427"xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/author | "Lowry P.J."xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/author | "Lowry P.J."xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/author | "Bennett H.P.J."xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/author | "Bennett H.P.J."xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/author | "McMartin C."xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/author | "McMartin C."xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/author | "Scott A.P."xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/author | "Scott A.P."xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/date | "1974"xsd:gYear |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/date | "1974"xsd:gYear |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/pages | "427-437"xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/pages | "427-437"xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/title | "The isolation and amino acid sequence of an adrenocorticotrophin from the pars distalis and a corticotrophin-like intermediate-lobe peptide from the neurointermediate lobe of the pituitary of the dogfish Squalus acanthias."xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/title | "The isolation and amino acid sequence of an adrenocorticotrophin from the pars distalis and a corticotrophin-like intermediate-lobe peptide from the neurointermediate lobe of the pituitary of the dogfish Squalus acanthias."xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/4375977 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/4375977 |
| http://purl.uniprot.org/citations/4375977 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/4375977 |