RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/4375978http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/4375978http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/4375978http://www.w3.org/2000/01/rdf-schema#comment"A melanocyte-stimulating hormone (MSH) has been isolated from extracts of the neurointermediate lobe of the pituitary of the dogfish Squalus acanthias by gel-filtration and ion-exchange chromatography. It had approximately 1% of the potency of mammalian alpha-MSH on bioassays in vitro on frog skin and dogfish skin. Sequence analysis revealed it to be a hexadecapeptide with the following primary structure: Asp-Gly-Asp-Asp-Tyr-Lys-Phe-Gly-His-Phe-Arg-Trp-Ser-Val-Pro-Leu. It appears to be related to the beta-MSH species of mammalian species but has only the sequence -His-Phe-Arg-Trp-in common with the heptapeptide core -Met-Glu-His-Phe-Arg-Trp-Gly-which is characteristic not only of the MSH peptides but also of the adrenocorticotrophins and lipotrophins studied so far. An alpha-MSH was also isolated, 50% of which was amidated at the C-terminus group. Sequence data from this study taken in conjunction with those from a previous study (Lowry & Chadwick, 1970b) revealed it to be a tridecapeptide which is identical with the N-terminal sequence of dogfish adrenocorticotrophin."xsd:string
http://purl.uniprot.org/citations/4375978http://purl.org/dc/terms/identifier"doi:10.1042/bj1410439"xsd:string
http://purl.uniprot.org/citations/4375978http://purl.org/dc/terms/identifier"doi:10.1042/bj1410439"xsd:string
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/author"Lowry P.J."xsd:string
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/author"Lowry P.J."xsd:string
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/author"Bennett H.P.J."xsd:string
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/author"Bennett H.P.J."xsd:string
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/author"McMartin C."xsd:string
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/author"McMartin C."xsd:string
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/author"Scott A.P."xsd:string
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/author"Scott A.P."xsd:string
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/date"1974"xsd:gYear
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/date"1974"xsd:gYear
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/name"Biochem. J."xsd:string
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/name"Biochem. J."xsd:string
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/pages"439-444"xsd:string
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/pages"439-444"xsd:string
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/title"Structural studies of alpha-melanocyte-stimulating hormone and a novel beta-melanocyte-stimulating hormone from the neurointermediate lobe of the pituitary of the dogfish Squalus acanthias."xsd:string
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/title"Structural studies of alpha-melanocyte-stimulating hormone and a novel beta-melanocyte-stimulating hormone from the neurointermediate lobe of the pituitary of the dogfish Squalus acanthias."xsd:string
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/volume"141"xsd:string
http://purl.uniprot.org/citations/4375978http://purl.uniprot.org/core/volume"141"xsd:string
http://purl.uniprot.org/citations/4375978http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/4375978
http://purl.uniprot.org/citations/4375978http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/4375978