| http://purl.uniprot.org/citations/4580557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/4580557 | http://www.w3.org/2000/01/rdf-schema#comment | "The effects of mutations occurring at three independent loci, eth2, eth3, and eth10, were studied on the basis of several criteria: level of resistance towards two methionine analogues (ethionine and selenomethionine), pool sizes of free methionine and S-adenosyl methionine (SAM) under different growth conditions, and susceptibility towards methionine-mediated repression and SAM-mediated repression of some enzymes involved in methionine biosynthesis (met group I enzymes). It was shown that: (i) the level of resistance towards both methionine analogues roughly correlates with the amount of methionine accumulated in the pool; (ii) the repressibility of met group I enzymes by exogenous methionine is either abolished or greatly lowered, depending upon the mutation studied; (iii) the repressibility of the same enzymes by exogenous SAM remains, in at least three mutants studied, close to that observed in a wild-type strain; (iv) the accumulation of SAM does not occur in the most extreme mutants either from endogenously overproduced or from exogenously supplied methionine: (v) the two methionine-activating enzymes, methionyl-transfer ribonucleic acid (tRNA) synthetase and methionine adenosyl transferase, do not seem modified in any of the mutants presented here; and (vi) the amount of tRNA(met) and its level of charging are alike in all strains. Thus, the three recessive mutations presented here affect methionine-mediated repression, both at the level of overall methionine biosynthesis which results in its accumulation in the pool, and at the level of the synthesis of met group I enzymes. The implications of these findings are discussed."xsd:string |
| http://purl.uniprot.org/citations/4580557 | http://purl.org/dc/terms/identifier | "doi:10.1128/jb.115.3.1084-1093.1973"xsd:string |
| http://purl.uniprot.org/citations/4580557 | http://purl.uniprot.org/core/author | "Cherest H."xsd:string |
| http://purl.uniprot.org/citations/4580557 | http://purl.uniprot.org/core/author | "Surdin-Kerjan Y."xsd:string |
| http://purl.uniprot.org/citations/4580557 | http://purl.uniprot.org/core/author | "de Robichon-Szulmajster H."xsd:string |
| http://purl.uniprot.org/citations/4580557 | http://purl.uniprot.org/core/author | "Antoniewski J."xsd:string |
| http://purl.uniprot.org/citations/4580557 | http://purl.uniprot.org/core/date | "1973"xsd:gYear |
| http://purl.uniprot.org/citations/4580557 | http://purl.uniprot.org/core/name | "J Bacteriol"xsd:string |
| http://purl.uniprot.org/citations/4580557 | http://purl.uniprot.org/core/pages | "1084-1093"xsd:string |
| http://purl.uniprot.org/citations/4580557 | http://purl.uniprot.org/core/title | "Effects of regulatory mutations upon methionine biosynthesis in Saccharomyces cerevisiae: loci eth2-eth3-eth10."xsd:string |
| http://purl.uniprot.org/citations/4580557 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/4580557 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/4580557 |
| http://purl.uniprot.org/citations/4580557 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/4580557 |
| http://purl.uniprot.org/uniprot/P10659#attribution-A2BA524A5A625880CD202DBE118D01B1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/4580557 |
| http://purl.uniprot.org/uniprot/#_P10659-mappedCitation-4580557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/4580557 |
| http://purl.uniprot.org/uniprot/P10659 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/4580557 |