| http://purl.uniprot.org/citations/6555050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
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| http://purl.uniprot.org/citations/6555050 | http://www.w3.org/2000/01/rdf-schema#comment | "Proelastase has been purified to homogeneity from rat pancreatic tissue by a combination of CM-Sephadex and immobilized protease inhibitor affinity resins. Trypsin activation yields an elastolytic enzyme that possesses a specificity toward small hydrophobic residues in synthetic amide substrates, similar to those of porcine elastase 1 and canine elastase. However, the rat enzyme also rapidly hydrolyzes a substrate containing tyrosine in the P1 position. N-Terminal sequence analysis reveals that rat proelastase has an identical activation peptide with that of porcine proelastase 1 and has two conservative amino acid sequence differences from the activation peptide of canine proelastase. The sequence data established that rat proelastase corresponds to the elastase 1 mRNA clone isolated by MacDonald et al. [MacDonald, R. J., Swift, G. H., Quinto, C., Swain, W., Pictet, R. L., Nikovits, W., & Rutter, W. J. (1982) Biochemistry 21, 1453]. The sequence and substrate data obtained for rat and canine elastases suggest that there is a family of pancreatic elastases with properties similar to those of the classically described porcine elastase 1."xsd:string |
| http://purl.uniprot.org/citations/6555050 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi00285a008"xsd:string |
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| http://purl.uniprot.org/citations/6555050 | http://purl.uniprot.org/core/author | "Largman C."xsd:string |
| http://purl.uniprot.org/citations/6555050 | http://purl.uniprot.org/core/author | "Largman C."xsd:string |
| http://purl.uniprot.org/citations/6555050 | http://purl.uniprot.org/core/date | "1983"xsd:gYear |
| http://purl.uniprot.org/citations/6555050 | http://purl.uniprot.org/core/date | "1983"xsd:gYear |
| http://purl.uniprot.org/citations/6555050 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/6555050 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/6555050 | http://purl.uniprot.org/core/pages | "3763-3770"xsd:string |
| http://purl.uniprot.org/citations/6555050 | http://purl.uniprot.org/core/pages | "3763-3770"xsd:string |
| http://purl.uniprot.org/citations/6555050 | http://purl.uniprot.org/core/title | "Isolation and characterization of rat pancreatic elastase."xsd:string |
| http://purl.uniprot.org/citations/6555050 | http://purl.uniprot.org/core/title | "Isolation and characterization of rat pancreatic elastase."xsd:string |
| http://purl.uniprot.org/citations/6555050 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/6555050 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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