| http://purl.uniprot.org/citations/6600227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/6600227 | http://www.w3.org/2000/01/rdf-schema#comment | "The frequency of HLA antigens was studied in 25 patients with primary sclerosing cholangitis and compared with a control group of 562 kidney donors. Fourteen patients also had ulcerative colitis. A significant increase in the frequency of HLA-B8 (60%) was found in the primary sclerosing cholangitis patients compared with controls (25%) (p less than 0.001). HLA-B8 was found in eight patients with ulcerative colitis. The frequency of HLA-B12 was significantly decreased (8%) compared with controls (30%) (p less than 0.02). Piecemeal necrosis was observed on liver histology in 66% of HLA-B8 positive and 50% of HLA-B8 negative patients. Low titres of serum autoantibodies were frequently found in the primary sclerosing cholangitis group but did not correspond to the presence of HLA-B8. Raised serum concentrations of IgM and IgG were not related to HLA-B8. This study has shown that in patients with primary sclerosing cholangitis there exists a disease susceptibility gene closely associated with the B locus of the major histocompatibility complex which may be modified by other factors such as ulcerative colitis. Patients with ulcerative colitis and HLA-B8 may be particularly liable to develop primary sclerosing cholangitis."xsd:string |
| http://purl.uniprot.org/citations/6600227 | http://purl.org/dc/terms/identifier | "doi:10.1136/gut.24.1.38"xsd:string |
| http://purl.uniprot.org/citations/6600227 | http://purl.uniprot.org/core/author | "Patel G."xsd:string |
| http://purl.uniprot.org/citations/6600227 | http://purl.uniprot.org/core/author | "Gaul R."xsd:string |
| http://purl.uniprot.org/citations/6600227 | http://purl.uniprot.org/core/author | "Chapman R.W."xsd:string |
| http://purl.uniprot.org/citations/6600227 | http://purl.uniprot.org/core/author | "Kokinon N."xsd:string |
| http://purl.uniprot.org/citations/6600227 | http://purl.uniprot.org/core/author | "Sherlock S."xsd:string |
| http://purl.uniprot.org/citations/6600227 | http://purl.uniprot.org/core/author | "Varghese Z."xsd:string |
| http://purl.uniprot.org/citations/6600227 | http://purl.uniprot.org/core/date | "1983"xsd:gYear |
| http://purl.uniprot.org/citations/6600227 | http://purl.uniprot.org/core/name | "Gut"xsd:string |
| http://purl.uniprot.org/citations/6600227 | http://purl.uniprot.org/core/pages | "38-41"xsd:string |
| http://purl.uniprot.org/citations/6600227 | http://purl.uniprot.org/core/title | "Association of primary sclerosing cholangitis with HLA-B8."xsd:string |
| http://purl.uniprot.org/citations/6600227 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/6600227 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/6600227 |
| http://purl.uniprot.org/citations/6600227 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/6600227 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-6600227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/6600227 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-6600227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/6600227 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-6600227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/6600227 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-6600227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/6600227 |
| http://purl.uniprot.org/uniprot/#_A0A068B107-mappedCitation-6600227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/6600227 |
| http://purl.uniprot.org/uniprot/#_A0A068B112-mappedCitation-6600227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/6600227 |
| http://purl.uniprot.org/uniprot/#_A0A068B116-mappedCitation-6600227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/6600227 |
| http://purl.uniprot.org/uniprot/#_A0A068B2J5-mappedCitation-6600227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/6600227 |
| http://purl.uniprot.org/uniprot/#_A0A068B2Z1-mappedCitation-6600227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/6600227 |