| http://purl.uniprot.org/citations/6605969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/6605969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/6605969 | http://www.w3.org/2000/01/rdf-schema#comment | "Monoclonal antibodies allow for the detection of structures on the cell surface of human cytotoxic thymus-derived lymphocytes, which are involved in their function. Among these cell surface components, T8 is of particular interest, since it is required during the recognition of target cells by a subset of human cytotoxic T lymphocytes. The only other cell types on which T8 has been detected are functionally inert thymocytes. Here we demonstrate that T8 isolated from peripheral blood T lymphocytes is different from thymocyte T8. On peripheral blood T lymphocytes T8 was found in multimeric forms of a 34-kDa glycoprotein. These forms were also found on thymocytes, but in addition multimeric complexes of the 34-kDa T8 with a 46-kDa protein were detected. Preliminary chemical analyses showed that the 34-kDa and the 46-kDa forms differ in both their protein and carbohydrate structures. The 46-kDa structure was found to be distinct from the major thymocyte antigen T10. The interchain disulfide bridges between the 34-kDa T8 polypeptide are located in the 24-kDa CNBr fragment, which contains a hydrophobic region. Two (14 kDa and 20 kDa) of the three CNBr fragments of the 46-kDa T8 subunit were found to be involved in interchain disulfide bridging with the 34-kDa T8 species. We suggest that the switch from heteromultimers to homomultimers may occur concomitantly with the last step in T lymphocyte maturation."xsd:string |
| http://purl.uniprot.org/citations/6605969 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(17)43915-9"xsd:string |
| http://purl.uniprot.org/citations/6605969 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(17)43915-9"xsd:string |
| http://purl.uniprot.org/citations/6605969 | http://purl.uniprot.org/core/author | "Terhorst C."xsd:string |
| http://purl.uniprot.org/citations/6605969 | http://purl.uniprot.org/core/author | "Terhorst C."xsd:string |
| http://purl.uniprot.org/citations/6605969 | http://purl.uniprot.org/core/author | "Snow P.M."xsd:string |
| http://purl.uniprot.org/citations/6605969 | http://purl.uniprot.org/core/author | "Snow P.M."xsd:string |
| http://purl.uniprot.org/citations/6605969 | http://purl.uniprot.org/core/date | "1983"xsd:gYear |
| http://purl.uniprot.org/citations/6605969 | http://purl.uniprot.org/core/date | "1983"xsd:gYear |
| http://purl.uniprot.org/citations/6605969 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/6605969 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/6605969 | http://purl.uniprot.org/core/pages | "14675-14681"xsd:string |
| http://purl.uniprot.org/citations/6605969 | http://purl.uniprot.org/core/pages | "14675-14681"xsd:string |
| http://purl.uniprot.org/citations/6605969 | http://purl.uniprot.org/core/title | "The T8 antigen is a multimeric complex of two distinct subunits on human thymocytes but consists of homomultimeric forms on peripheral blood T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/6605969 | http://purl.uniprot.org/core/title | "The T8 antigen is a multimeric complex of two distinct subunits on human thymocytes but consists of homomultimeric forms on peripheral blood T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/6605969 | http://purl.uniprot.org/core/volume | "258"xsd:string |
| http://purl.uniprot.org/citations/6605969 | http://purl.uniprot.org/core/volume | "258"xsd:string |
| http://purl.uniprot.org/citations/6605969 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/6605969 |
| http://purl.uniprot.org/citations/6605969 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/6605969 |
| http://purl.uniprot.org/citations/6605969 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/6605969 |
| http://purl.uniprot.org/citations/6605969 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/6605969 |
| http://purl.uniprot.org/uniprot/P01732 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/6605969 |
| http://purl.uniprot.org/uniprot/P01732#attribution-FADCB8A1A040432BEE3A10B03856DE3C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/6605969 |