| http://purl.uniprot.org/citations/6699408 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/6699408 | http://www.w3.org/2000/01/rdf-schema#comment | "The control mechanisms responsible for the innate resistance of C57BL/6J (B) mice and for the innate susceptibility of A/J (A) mice to infection with Listeria monocytogenes were studied by typing the recombinant inbred (RI) strains derived from these two progenitors for the trait of Listeria resistance/susceptibility. The strain distribution pattern (SDP) of this trait obtained in the 13 AXB/BXA RI strains studied suggests that an allelic difference at a major locus (Lr-1) is responsible for the trait of resistance/susceptibility to Listeria. In addition, another putative gene (Lr-2) unlinked to Lr-1 is postulated to control the level of bacterial load within the group of susceptible strains. The SDP of A and B alleles at the Lr-1 locus was fully concordant with that observed for the Hc locus (controlling the level of the C5 component of complement). This suggests that the genetic susceptibility of A strains of mice to Listeria infection is either directly due to or related to the C5 deficiency found in that strain. This conclusion is enhanced by the observation of a significant protection of A mice from listeriosis by the infusion of C5-rich serum. A survey of RI strains for the magnitude of PMN and macrophage inflammatory responses showed that the expression of both traits co-segregated and that the C5 deficiency was the major factor responsible for the defective inflammatory response of A strain mice. We conclude that a defect in the phagocyte inflammatory responses caused by C5 deficiency is the major reason for the extreme susceptibility of A mice to Listeria."xsd:string |
| http://purl.uniprot.org/citations/6699408 | http://purl.uniprot.org/core/author | "Stevenson M."xsd:string |
| http://purl.uniprot.org/citations/6699408 | http://purl.uniprot.org/core/author | "Skamene E."xsd:string |
| http://purl.uniprot.org/citations/6699408 | http://purl.uniprot.org/core/author | "Gervais F."xsd:string |
| http://purl.uniprot.org/citations/6699408 | http://purl.uniprot.org/core/date | "1984"xsd:gYear |
| http://purl.uniprot.org/citations/6699408 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/6699408 | http://purl.uniprot.org/core/pages | "2078-2083"xsd:string |
| http://purl.uniprot.org/citations/6699408 | http://purl.uniprot.org/core/title | "Genetic control of resistance to Listeria monocytogenes: regulation of leukocyte inflammatory responses by the Hc locus."xsd:string |
| http://purl.uniprot.org/citations/6699408 | http://purl.uniprot.org/core/volume | "132"xsd:string |
| http://purl.uniprot.org/citations/6699408 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/6699408 |
| http://purl.uniprot.org/citations/6699408 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/6699408 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUU3-mappedCitation-6699408 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/6699408 |
| http://purl.uniprot.org/uniprot/#_Q8BNV3-mappedCitation-6699408 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/6699408 |
| http://purl.uniprot.org/uniprot/#_Q99KX9-mappedCitation-6699408 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/6699408 |
| http://purl.uniprot.org/uniprot/#_P06684-mappedCitation-6699408 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/6699408 |
| http://purl.uniprot.org/uniprot/P06684 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/6699408 |
| http://purl.uniprot.org/uniprot/Q8BNV3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/6699408 |
| http://purl.uniprot.org/uniprot/A0A0J9YUU3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/6699408 |
| http://purl.uniprot.org/uniprot/Q99KX9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/6699408 |