| http://purl.uniprot.org/citations/6762206 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/6762206 | http://www.w3.org/2000/01/rdf-schema#comment | "Electrophoretic and activity variants for a liver aldehyde reductase (AHR-A2) among strains of Mus musculus have been used in genetic analyses to demonstrate close linkage between the locus encoding this enzyme (designated Ahr-1) and the alcohol dehydrogenase gene complex on chromosome 3. No recombinants were observed between Adh-3 (encoding alcohol dehydrogenase C2; ADH-C2) and Ahr-1 among 42 backcross animals. Moreover, linkage disequilibrium between these loci was observed among 58 of 60 strains of mice examined and among seven recombinant inbred strains derived from C57BL/6J and BALB/c mice. Liver hexonate dehydrogenase (HDH-A) was electrophoretically invariant among the strains examined. Gel filtration analyses demonstrated that AHR-A2 and HDH-A had native molecular weights of approximately 80,000 and 32,000, respectively. Three-banded allozyme patterns for AHR-A2 in CBA/H x castaneus hybrid animals were consistent with a dimeric subunit structure. Comparative substrate and coenzyme specificities for AHR-A2, HDH-A, and ADH-A2 (liver ADH isozyme) were examined. AHR-A2 exhibited a defined specificity toward p-nitrobenzaldehyde as substrate, whereas the other enzymes exhibited broad specificities toward various aliphatic, aromatic, and monosaccharide aldehydes. It is proposed that Ahr-1 is a product of a gene duplication event during mammalian evolution of the primordial mammalian Adh locus and that considerable divergence in catalytic properties has subsequently occurred."xsd:string |
| http://purl.uniprot.org/citations/6762206 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf00498933"xsd:string |
| http://purl.uniprot.org/citations/6762206 | http://purl.uniprot.org/core/author | "Duley J.A."xsd:string |
| http://purl.uniprot.org/citations/6762206 | http://purl.uniprot.org/core/author | "Holmes R.S."xsd:string |
| http://purl.uniprot.org/citations/6762206 | http://purl.uniprot.org/core/date | "1982"xsd:gYear |
| http://purl.uniprot.org/citations/6762206 | http://purl.uniprot.org/core/name | "Biochem Genet"xsd:string |
| http://purl.uniprot.org/citations/6762206 | http://purl.uniprot.org/core/pages | "1067-1083"xsd:string |
| http://purl.uniprot.org/citations/6762206 | http://purl.uniprot.org/core/title | "Biochemical genetics of aldehyde reductase in the mouse: Ahr-1--a new locus linked to the alcohol dehydrogenase gene complex on chromosome 3."xsd:string |
| http://purl.uniprot.org/citations/6762206 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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