| http://purl.uniprot.org/citations/6822734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/6822734 | http://www.w3.org/2000/01/rdf-schema#comment | "The nature of cell surface determinants detected by Qa-1-specific alloantisera and cytotoxic T lymphocytes (CTL) in mice of the H-2f, Qa-1d genotype was investigated. The H-2f, Qa-1d strains A.CA and B10.M express both Qa-1a and Qa-1b encoded alloantigenic determinants (Qa-1.1 and Qa-1.2, respectively), as defined in the prototypic A (or B6-Tlaa) and C57BL/6 (or A-Tlab) strains, respectively. Both anti-Qa-1.1 and -Qa-1.2 sera immunoprecipitate 46K m.w. glycoproteins from H-2f, Qa-1d strains. In addition to 46K m.w. proteins, anti-Qa-1.1 sera, but not anti-Qa-1.2 sera, precipitate 55 to 75K m.w. proteins; the nature of these proteins and their relationship to Qa-1 is unclear at present. Sequential immunoprecipitation experiments and the analysis of several recombinant strains revealed that anti-Qa-1.1 sera also cross-react with a 46K m.w. H-2f-encoded alloantigen, probably H-2Kf. Both Qa-1.1 and the non-Qa-1.1 cross-reacting determinants were detected by polyclonal anti-Qa-1a CTL on the Qa-1d strains. The Qa-1a encoded but not the cross-reacting determinants were detected by a cloned anti-Qa-1a CTL line. Sequential immunoprecipitation experiments on the recombinant strains B6.AC2 and B10.M(17R), which are Qa-1d but not H-2Kf, revealed that the Qa-1.1 and Qa-1.2 determinants do not reside on the same molecule. Furthermore, although Qa-1b-encoded determinants were detected on these strains with anti-sera and with bulk CTL cultures, cloned anti-Qa-1b CTL lines thus far analyzed have failed to react with Qa-1d targets, indicating that some but not all of the prototypic Qa-1b-encoded determinants are expressed by the Qa-1d strains."xsd:string |
| http://purl.uniprot.org/citations/6822734 | http://purl.uniprot.org/core/author | "Cook R.G."xsd:string |
| http://purl.uniprot.org/citations/6822734 | http://purl.uniprot.org/core/author | "Rich R.R."xsd:string |
| http://purl.uniprot.org/citations/6822734 | http://purl.uniprot.org/core/author | "Jenkins R.N."xsd:string |
| http://purl.uniprot.org/citations/6822734 | http://purl.uniprot.org/core/author | "Flaherty L."xsd:string |
| http://purl.uniprot.org/citations/6822734 | http://purl.uniprot.org/core/date | "1983"xsd:gYear |
| http://purl.uniprot.org/citations/6822734 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/6822734 | http://purl.uniprot.org/core/pages | "1293-1299"xsd:string |
| http://purl.uniprot.org/citations/6822734 | http://purl.uniprot.org/core/title | "The Qa-1 alloantigens. II. Evidence for the expression of two Qa-1 molecules by the Qa-1d genotype and for cross-reactivity between Qa-1 and H-2K."xsd:string |
| http://purl.uniprot.org/citations/6822734 | http://purl.uniprot.org/core/volume | "130"xsd:string |
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