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http://purl.uniprot.org/citations/6947235 | http://www.w3.org/2000/01/rdf-schema#comment | "A genetic polymorphism for a Bgl I endonuclease site near the alpha-globin-like pseudogene alpha-4 of C57BL/6 and C3H/HeN mice was used to show that alpha-4 was not affected by three independent mutations in which the adult globin genes alpha-1 and alpha-2 were deleted. These results indicated that alpha-4 might not be located adjacent to the adult alpha-globin genes on chromosome 11. Restriction endonuclease analysis of DNA of a primary clone of a Chinese hamster--mouse somatic cell hybrid that had lost mouse chromosomes 11 and 18 showed that this clone lacked the adult murine globin genes alpha-1 and alpha-2 but it did contain the alpha-globin-like pseudogenes alpha-3 and alpha-4. These results indicated that the adult alpha-globin genes and alpha-globin-like pseudogenes are not located on the same chromosome. Similar analyses of several other Chinese hamster--mouse somatic cell hybrids that had segregated other mouse chromosomes indicated that the alpha-globin-like pseudogenes alpha-3 and alpha-4 are located on mouse chromosomes 15 and 17, respectively. These data explain why alpha-3 and alpha-4 were not affected by the three independently induced deletion-type mutations that cause alpha-thalassemia in the mouse."xsd:string |
http://purl.uniprot.org/citations/6947235 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.78.10.6362"xsd:string |
http://purl.uniprot.org/citations/6947235 | http://purl.uniprot.org/core/author | "Anderson W.F."xsd:string |
http://purl.uniprot.org/citations/6947235 | http://purl.uniprot.org/core/author | "Whitney J.B."xsd:string |
http://purl.uniprot.org/citations/6947235 | http://purl.uniprot.org/core/author | "Lalley P.A."xsd:string |
http://purl.uniprot.org/citations/6947235 | http://purl.uniprot.org/core/author | "Popp R.A."xsd:string |
http://purl.uniprot.org/citations/6947235 | http://purl.uniprot.org/core/date | "1981"xsd:gYear |
http://purl.uniprot.org/citations/6947235 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
http://purl.uniprot.org/citations/6947235 | http://purl.uniprot.org/core/pages | "6362-6366"xsd:string |
http://purl.uniprot.org/citations/6947235 | http://purl.uniprot.org/core/title | "Mouse alpha-globin genes and alpha-globin-like pseudogenes are not syntenic."xsd:string |
http://purl.uniprot.org/citations/6947235 | http://purl.uniprot.org/core/volume | "78"xsd:string |
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