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| http://purl.uniprot.org/citations/7035824 | http://www.w3.org/2000/01/rdf-schema#comment | "Heme-deficient mutants of Saccharomyces cerevisiae have been isolated from two isogenic strains with the use of an enrichment method based on photodynamic properties of Zn-protoporphyrin. They defined seven non-overlapping complementation groups. A mutant representative of each group was further analysed. Genetic analysis showed that each mutant carried a single nuclear recessive mutations. Biochemical studies showed that the observed accumulation and/or excretion of the different heme synthesis precursors by the mutant cells correlated well with the enzymatic deficiencies measured in acellular extracts. Six of the seven mutants were blocked in a different enzyme activity: 5-aminolevulinate synthase, porphobilinogen synthase, uroporphyrinogen I synthase, uroporphyrinogen decarboxylase, coproporphyrinogen III oxidase and ferrochelatase. The other mutant had the same phenotype as the mutant deficient in ferrochelatase activity. However, it possessed a normal ferrochelatase activity when measured in vitro, so this mutant was assumed to be deficient in protoporphyrinogen oxidase activity or in the transport and/or reduction of iron. The absence of PBG synthesis led to a total lack of uroporphyrinogen I synthase activity. The absence of heme, the end product, led to an important increase of coproporphyrinogen III oxidase activity, while the activity of 5-aminolevulinate synthase, the first enzyme of the pathway, was not changed. These results are discussed in terms of possible modes of regulation of heme synthesis pathway in yeast."xsd:string |
| http://purl.uniprot.org/citations/7035824 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf00270144"xsd:string |
| http://purl.uniprot.org/citations/7035824 | http://purl.uniprot.org/core/author | "Labbe-Bois R."xsd:string |
| http://purl.uniprot.org/citations/7035824 | http://purl.uniprot.org/core/author | "Urban-Grimal D."xsd:string |
| http://purl.uniprot.org/citations/7035824 | http://purl.uniprot.org/core/date | "1981"xsd:gYear |
| http://purl.uniprot.org/citations/7035824 | http://purl.uniprot.org/core/name | "Mol Gen Genet"xsd:string |
| http://purl.uniprot.org/citations/7035824 | http://purl.uniprot.org/core/pages | "85-92"xsd:string |
| http://purl.uniprot.org/citations/7035824 | http://purl.uniprot.org/core/title | "Genetic and biochemical characterization of mutants of Saccharomyces cerevisiae blocked in six different steps of heme biosynthesis."xsd:string |
| http://purl.uniprot.org/citations/7035824 | http://purl.uniprot.org/core/volume | "183"xsd:string |
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