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| http://purl.uniprot.org/citations/7042346 | http://www.w3.org/2000/01/rdf-schema#comment | "Saccharomyces cerevisiae mutants lacking the anabolic L-threonine deaminase, the ilv1-mutants, have been found to exhibit a normal ability to grow, without auxotrophy towards isoleucine, on L-threonine of L-serine as only nitrogen nutrient. Starting from a strain carrying a ilv1-mutation, a new mutation affecting the ability to utilize L-threonine as nitrogen source was selected. This mutation, which also impairs the ability to utilize L-serine, has been denominated cha-, for 'catabolism of hydroxyamino acids' and was found to result in the lack of a catabolic L-serine (L-threonine) deaminase. This enzyme which, unlike the anabolic threonine deaminase, is more active towards serine than towards threonine, differs from the latter enzyme by a number of biochemical and regulatory properties. Whereas the anabolic enzyme is an allosteric enzyme sensitive to feedback inhibition by isoleucine, the catabolic enzyme exhibits Michaelian kinetics: no control of its activity has been detected. Its synthesis is induced by L-serine and L-threonine. These two enzymes, which thus can be easily differentiated by means of their regulations, display a limited ability to compensate for one another's absence and appear to play clearly distinct roles under normal physiological conditions."xsd:string |
| http://purl.uniprot.org/citations/7042346 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1432-1033.1982.tb06570.x"xsd:string |
| http://purl.uniprot.org/citations/7042346 | http://purl.uniprot.org/core/author | "Ramos F."xsd:string |
| http://purl.uniprot.org/citations/7042346 | http://purl.uniprot.org/core/author | "Wiame J.M."xsd:string |
| http://purl.uniprot.org/citations/7042346 | http://purl.uniprot.org/core/date | "1982"xsd:gYear |
| http://purl.uniprot.org/citations/7042346 | http://purl.uniprot.org/core/name | "Eur J Biochem"xsd:string |
| http://purl.uniprot.org/citations/7042346 | http://purl.uniprot.org/core/pages | "571-576"xsd:string |
| http://purl.uniprot.org/citations/7042346 | http://purl.uniprot.org/core/title | "Occurrence of a catabolic L-serine (L-threonine) deaminase in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/7042346 | http://purl.uniprot.org/core/volume | "123"xsd:string |
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