| http://purl.uniprot.org/citations/7447922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7447922 | http://www.w3.org/2000/01/rdf-schema#comment | "A new mouse strain, the V strain, with a partial deficiency of phosphorylase kinase has been established. The deficiency is caused by an X-linked dominant gene (PhKc). Muscle extracts of homozygous and heterozygous females and hemizygous males have about 25% of the activity found in extracts of normal (C3H/HeHan) mice. This dominant phosphorylase kinase deficiency of the new V strain is different from that of the I-strain mice with the X-linked recessive deficiency of skeletal muscle phosphorylase kinase. The muscle extracts of V-strain and normal mice contain the same phosphorylase phosphatase activity of about 1 U/mg. Heart and liver extracts from V mice contained about 50% and 66%, respectively, of the phosphorylase kinase activity compared to that found in the same organs from the normal mice. The glycogen content of the skeletal muscle of the V strain was normal, i.e., 0.9 mg/g. Phosphorylase kinase was purified from the skeletal muscle of the V strain by (a) hydrophobic chromatography on methylamine Sepharose, (b) ammonium sulfate precipitation, and (c) gel filtration of Sepharose 4B. The enzyme has a similar structure to the normal murine and rabbit skeletal muscle enzyme, except that the proportion of the subunits differs. The molar ratio of the subunits of the V strain mice is (alpha + alpha'):beta:gamma=0.54:1:1.169, in comparison with that of the rabbit (alpha + alpha'):beta:gamma=1.1:1.0:1.0 and that of normal murine enzyme 0.9:1.0:0.7."xsd:string |
| http://purl.uniprot.org/citations/7447922 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf00484240"xsd:string |
| http://purl.uniprot.org/citations/7447922 | http://purl.uniprot.org/core/author | "Varsanyi M."xsd:string |
| http://purl.uniprot.org/citations/7447922 | http://purl.uniprot.org/core/author | "Heilmeyer L.M. Jr."xsd:string |
| http://purl.uniprot.org/citations/7447922 | http://purl.uniprot.org/core/author | "Vrbica A."xsd:string |
| http://purl.uniprot.org/citations/7447922 | http://purl.uniprot.org/core/date | "1980"xsd:gYear |
| http://purl.uniprot.org/citations/7447922 | http://purl.uniprot.org/core/name | "Biochem Genet"xsd:string |
| http://purl.uniprot.org/citations/7447922 | http://purl.uniprot.org/core/pages | "247-261"xsd:string |
| http://purl.uniprot.org/citations/7447922 | http://purl.uniprot.org/core/title | "X-linked dominant inheritance of partial phosphorylase kinase deficiency in mice."xsd:string |
| http://purl.uniprot.org/citations/7447922 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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