| http://purl.uniprot.org/citations/7473749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7473749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7473749 | http://www.w3.org/2000/01/rdf-schema#comment | "The three-dimensional solution structure of bombyxin-II, an insulin-like two-chain peptide produced by the brain of the silkworm Bombyx mori, has been determined by simulated annealing calculations based on 535 distance constraints and 24 torsion-angle constraints derived from NMR data and three distance constraints of the disulfide bonds. To our knowledge, this is the first three-dimensional structure determined for an invertebrate insulin-related peptide. The root-mean-square deviations between the best 10 structures and the mean structure are 0.58(+/-0.15) A for the backbone heavy atoms (N, C alpha, C) and 1.03(+/-0.18) A for all non-hydrogen atom if less well-defined N and C termini (A1, A20, B(-2) to B4 and B23 to B25) are excluded. The overall main-chain structure of bombyxin-II is similar to that of insulin. However, there are significant conformational and functional differences in their B-chain C-terminal parts. The B-chain C-terminal part of bombyxin-II adopts an extension of the B-chain central helix like that of relaxin and is not required for bombyxin activity, while the corresponding part of insulin adopts a sharp turn and a beta-strand and is essential for insulin activity. This structure demonstrates that bombyxin-II is more closely related to relaxin than to insulin, and suggests that insulin might have evolved the additional receptor-recognition site in the B-chain C-terminal beta-strand to distinguish itself from bombyxin and relaxin. The structure of bombyxin-II thus provides novel insights into the receptor recognition and divergent molecular evolution of insulin-superfamily peptides."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.org/dc/terms/identifier | "doi:10.1006/jmbi.1995.0588"xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.org/dc/terms/identifier | "doi:10.1006/jmbi.1995.0588"xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Inagaki F."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Inagaki F."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Hatanaka H."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Hatanaka H."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Kohda D."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Kohda D."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Kataoka H."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Kataoka H."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Suzuki A."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Suzuki A."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Nagata K."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Nagata K."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Nagasawa H."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Nagasawa H."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Isogai A."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Isogai A."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Ishizaki H."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/author | "Ishizaki H."xsd:string |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7473749 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |