| http://purl.uniprot.org/citations/7479848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7479848 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear translocation of NF-kappa B follows the degradation of its inhibitor, I kappa B alpha, an event coupled with stimulation-dependent inhibitor phosphorylation. Prevention of the stimulation-dependent phosphorylation of I kappa B alpha, either by treating cells with various reagents or by mutagenesis of certain putative I kappa B alpha phosphorylation sites, abolishes the inducible degradation of I kappa B alpha. Yet, the mechanism coupling the stimulation-induced phosphorylation with the degradation has not been resolved. Recent reports suggest a role for the proteasome in I kappa B alpha degradation, but the mode of substrate recognition and the involvement of ubiquitin conjugation as a targeting signal have not been addressed. We show that of the two forms of I kappa B alpha recovered from stimulated cells in a complex with RelA and p50, only the newly phosphorylated form, pI kappa B alpha, is a substrate for an in vitro reconstituted ubiquitin-proteasome system. Proteolysis requires ATP, ubiquitin, a specific ubiquitin-conjugating enzyme, and other ubiquitin-proteasome components. In vivo, inducible I kappa B alpha degradation requires a functional ubiquitin-activating enzyme and is associated with the appearance of high molecular weight adducts of I kappa B alpha. Ubiquitin-mediated protein degradation may, therefore, constitute an integral step of a signal transduction process."xsd:string |
| http://purl.uniprot.org/citations/7479848 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.92.23.10599"xsd:string |
| http://purl.uniprot.org/citations/7479848 | http://purl.uniprot.org/core/author | "Ciechanover A."xsd:string |
| http://purl.uniprot.org/citations/7479848 | http://purl.uniprot.org/core/author | "Orian A."xsd:string |
| http://purl.uniprot.org/citations/7479848 | http://purl.uniprot.org/core/author | "Yaron A."xsd:string |
| http://purl.uniprot.org/citations/7479848 | http://purl.uniprot.org/core/author | "Ben-Neriah Y."xsd:string |
| http://purl.uniprot.org/citations/7479848 | http://purl.uniprot.org/core/author | "Alkalay I."xsd:string |
| http://purl.uniprot.org/citations/7479848 | http://purl.uniprot.org/core/author | "Hatzubai A."xsd:string |
| http://purl.uniprot.org/citations/7479848 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7479848 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/7479848 | http://purl.uniprot.org/core/pages | "10599-10603"xsd:string |
| http://purl.uniprot.org/citations/7479848 | http://purl.uniprot.org/core/title | "Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway."xsd:string |
| http://purl.uniprot.org/citations/7479848 | http://purl.uniprot.org/core/volume | "92"xsd:string |
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