| http://purl.uniprot.org/citations/7479914 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7479914 | http://www.w3.org/2000/01/rdf-schema#comment | "The orphan nuclear receptor steroidogenic factor 1 (SF-1) is expressed in the adrenal cortex and gonads and regulates the expression of several P450 steroid hydroxylases in vitro. We examined the role of SF-1 in the adrenal glands and gonads in vivo by a targeted disruption of the mouse SF-1 gene. All SF-1-deficient mice died shortly after delivery. Their adrenal glands and gonads were absent, and persistent Mullerian structures were found in all genotypic males. While serum levels of corticosterone in SF-1-deficient mice were diminished, levels of adrenocorticotropic hormone (ACTH) were elevated, consistent with intact pituitary corticotrophs. Intrauterine survival of SF-1-deficient mice appeared normal, and they had normal serum level of corticosterone and ACTH, probably reflecting transplacental passage of maternal steroids. We tested whether SF-1 is required for P450 side-chain-cleavage enzyme (P450scc) expression in the placenta, which expresses both SF-1 and P450scc, and found that in contrast to its strong activation of the P450scc gene promoter in vitro, the absence of SF-1 had no effect on P450scc mRNA levels in vivo. Although the region targeted by our disruption is shared by SF-1 and by embryonal long terminal repeat-binding protein (ELP), a hypothesized alternatively spliced product, we believe that the observed phenotype reflects absent SF-1 alone, as PCR analysis failed to detect ELP transcripts in any mouse tissue, and sequences corresponding to ELP are not conserved across species. These results confirm that SF-1 is an important regulator of adrenal and gonadal development, but its regulation of steroid hydroxylase expression in vivo remains to be established."xsd:string |
| http://purl.uniprot.org/citations/7479914 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.92.24.10939"xsd:string |
| http://purl.uniprot.org/citations/7479914 | http://purl.uniprot.org/core/author | "Milbrandt J."xsd:string |
| http://purl.uniprot.org/citations/7479914 | http://purl.uniprot.org/core/author | "Crawford P.A."xsd:string |
| http://purl.uniprot.org/citations/7479914 | http://purl.uniprot.org/core/author | "Sadovsky Y."xsd:string |
| http://purl.uniprot.org/citations/7479914 | http://purl.uniprot.org/core/author | "Polish J.A."xsd:string |
| http://purl.uniprot.org/citations/7479914 | http://purl.uniprot.org/core/author | "Clements M.A."xsd:string |
| http://purl.uniprot.org/citations/7479914 | http://purl.uniprot.org/core/author | "Simburger K."xsd:string |
| http://purl.uniprot.org/citations/7479914 | http://purl.uniprot.org/core/author | "Tourtellotte L.M."xsd:string |
| http://purl.uniprot.org/citations/7479914 | http://purl.uniprot.org/core/author | "Woodson K.G."xsd:string |
| http://purl.uniprot.org/citations/7479914 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7479914 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/7479914 | http://purl.uniprot.org/core/pages | "10939-10943"xsd:string |
| http://purl.uniprot.org/citations/7479914 | http://purl.uniprot.org/core/title | "Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids."xsd:string |
| http://purl.uniprot.org/citations/7479914 | http://purl.uniprot.org/core/volume | "92"xsd:string |
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