| http://purl.uniprot.org/citations/7489501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7489501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7489501 | http://www.w3.org/2000/01/rdf-schema#comment | "In virtually all vertebrate cells, Ro RNPs consist of the 60-kDa Ro autoantigen bound to one of several small cytoplasmic RNA molecules known as Y RNAs. Because the 60-kDa Ro autoantigen is also found complexed with defective precursors of 5S rRNA in Xenopus oocytes, we have proposed that this protein functions in a quality control, or discard pathway, for 5S RNA biosynthesis (O'Brien CA, Wolin SL, 1994, Genes & Dev 8:2891-2903). The role of the Y RNAs in this pathway is unknown. To begin a genetic analysis of Ro RNP function, we have characterized these particles in the nematode Caenorhabditis elegans. The C. elegans Ro protein is 12 kDa larger than the vertebrate protein; the larger size is due in part to an N-terminal extension and to two insertions in the RNA recognition motif. In contrast to all previously described vertebrate species, the Ro protein appears bound to a single Y RNA in C. elegans. Similar to vertebrate Y RNAs, the C. elegans Y RNA can be folded to form a pyrimidine-rich internal loop and a long stem in which the 5' and 3' ends are base paired. Within the stem is a conserved bulged helix that is proposed to be the binding site of the Ro protein. Interestingly, although the human protein can bind the nematode Y RNA, the C. elegans protein does not bind human Y RNAs. This is the first description of Ro RNPs in an invertebrate species."xsd:string |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/author | "Eisenberg D."xsd:string |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/author | "Eisenberg D."xsd:string |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/author | "Wolin S.L."xsd:string |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/author | "Wolin S.L."xsd:string |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/author | "O'Brien C.A."xsd:string |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/author | "O'Brien C.A."xsd:string |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/author | "Van Horn D.J."xsd:string |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/author | "Van Horn D.J."xsd:string |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/name | "RNA"xsd:string |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/name | "RNA"xsd:string |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/pages | "293-303"xsd:string |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/pages | "293-303"xsd:string |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/title | "Caenorhabditis elegans embryos contain only one major species of Ro RNP."xsd:string |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/title | "Caenorhabditis elegans embryos contain only one major species of Ro RNP."xsd:string |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/volume | "1"xsd:string |
| http://purl.uniprot.org/citations/7489501 | http://purl.uniprot.org/core/volume | "1"xsd:string |
| http://purl.uniprot.org/citations/7489501 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7489501 |
| http://purl.uniprot.org/citations/7489501 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7489501 |
| http://purl.uniprot.org/citations/7489501 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7489501 |
| http://purl.uniprot.org/citations/7489501 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7489501 |