| http://purl.uniprot.org/citations/7499852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7499852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7499852 | http://www.w3.org/2000/01/rdf-schema#comment | "Surfactant protein-D (SP-D) is a collectin found associated with surfactant in the lung. SP-D has also been functionally characterized as an opsonin for diverse microorganisms and a chemoattractant for phagocytic cells. To determine the structure of mouse SP-D, we isolated and characterized clones from a B6/CBAF1J strain lung cDNA library using a PCR-derived genomic probe. The deduced sequence predicts a 19-amino acid signal sequence, a 25-amino acid long NH2 terminus with two cysteines, followed by an uninterrupted collagen domain with 59 Gly-X-Y repeats. Next, a short "neck" domain of 28 amino acids, with a potential to form trimeric alpha-helical coiled coil is found ending in a COOH-terminal 125-amino acid carbohydrate recognition domain. The mature mouse SP-D protein of 355 amino acids shows strong homology to rat (92% identity), human (76%), and bovine (72%) SP-D amino acid sequences. Northern blot and RT-PCR analysis revealed that the mouse SP-D gene is expressed predominantly in lung and, surprisingly, also in heart, stomach, and kidney but not in brain. In contrast, mouse surfactant protein-A (SP-A) mRNA expression was found to be restricted to lung. Human lung and stomach, but not heart or liver, were found to express SP-D mRNA, as determined by PCR. The mouse SP-D gene (Sftp4) has been localized to chromosome 14 (to a region syntenic to human chromosome 10), closely linked to the genes for other collagenous lectins, mannose-binding protein-A (MbI1), and SP-A (Sftp1)."xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/author | "Tauber A.I."xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/author | "Tauber A.I."xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/author | "Guo N."xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/author | "Guo N."xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/author | "White R.A."xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/author | "White R.A."xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/author | "Sastry K.N."xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/author | "Sastry K.N."xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/author | "Dowler L.L."xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/author | "Dowler L.L."xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/author | "Motwani M."xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/author | "Motwani M."xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/pages | "5671-5677"xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/pages | "5671-5677"xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/title | "Mouse surfactant protein-D. cDNA cloning, characterization, and gene localization to chromosome 14."xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/title | "Mouse surfactant protein-D. cDNA cloning, characterization, and gene localization to chromosome 14."xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/volume | "155"xsd:string |
| http://purl.uniprot.org/citations/7499852 | http://purl.uniprot.org/core/volume | "155"xsd:string |