| http://purl.uniprot.org/citations/7503239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7503239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7503239 | http://www.w3.org/2000/01/rdf-schema#comment | "The effects of cytokines, lipopolysaccharide (LPS), 8-bromoadenosine 3',5'-cyclic monophosphate (8-BrcAMP), and pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappa B (NF-kappa B) activation, on inducible nitric oxide synthase (iNOS) expression were studied in the medullary thick ascending limb of Henle's loop cell line ST-1. LPS + interferon-gamma (IF-gamma) promoted a time-dependent increase in nitrite (a NO metabolite) and iNOS mRNA and the appearance of NF-kappa B p50 and p65 in nuclear protein extracts. Actinomycin D but not cycloheximide prevented the LPS + IF-gamma induction of iNOS mRNA and NO synthesis, indicating that iNOS transcriptional activation by LPS + IF-gamma does not require newly synthesized proteins. PDTC inhibited the LPS + IF-gamma induction of NO, iNOS mRNA, and the appearance of NF-kappa B in nuclear protein extracts, suggesting that NF-kappa B mobilization and trans-activation of the iNOS gene mediates this induction. In contrast to other cell types, cycloheximide did not alter iNOS mRNA stability, and 8-BrcAMP did not alter basal or LPS+IF-gamma induced NO production in ST-1 cells."xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.1995.269.5.f718"xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.1995.269.5.f718"xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/author | "Turner P."xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/author | "Turner P."xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/author | "Kone B.C."xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/author | "Kone B.C."xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/author | "Cangro C.B."xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/author | "Cangro C.B."xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/author | "Mohaupt M.G."xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/author | "Mohaupt M.G."xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/author | "Schwoebel J."xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/author | "Schwoebel J."xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/name | "Am. J. Physiol."xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/name | "Am. J. Physiol."xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/pages | "F718-F729"xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/pages | "F718-F729"xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/title | "Role of NF-kappa B in the regulation of inducible nitric oxide synthase in an MTAL cell line."xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/title | "Role of NF-kappa B in the regulation of inducible nitric oxide synthase in an MTAL cell line."xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/volume | "269"xsd:string |
| http://purl.uniprot.org/citations/7503239 | http://purl.uniprot.org/core/volume | "269"xsd:string |