| http://purl.uniprot.org/citations/7509023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7509023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7509023 | http://www.w3.org/2000/01/rdf-schema#comment | "The conservation in evolution of fundamental signal transduction modules offers a means of isolating genes likely to be involved in plant development. We have amplified by PCR Arabidopsis cDNA and genomic sequences related to the product of the shaggy/zeste-white 3 (sgg) segment polarity gene of Drosophila. This regulatory protein is functionally homologous to glycogen synthase kinase-3 in mammals (GSK-3), which regulates, among others, the DNA-binding activity of the c-jun/AP1 transcription factor. Analysis of PCR products led to the identification of five genes; for two of which, corresponding full-length cDNAs, ASK-alpha and gamma (for Arabidopsis shaggy-related protein kinase), were characterized. The encoded proteins were 70% identical to GSK-3 and sgg over the protein kinase catalytic domain and, after production in Escherichia coli, autophosphorylated mainly on threonine and serine residues, but phosphotyrosine was also detected. ASK-alpha and ASK-gamma also phosphorylated phosphatase inhibitor-2 and myelin basic protein, on threonine and serine, respectively. The high conservation of the protein kinases of GSK-3 family, and their action at the transcriptional level, suggest that the ASK proteins have important functions in higher plants."xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf00280424"xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf00280424"xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/author | "Kreis M."xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/author | "Kreis M."xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/author | "Woodgett J.R."xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/author | "Woodgett J.R."xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/author | "Thomas M."xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/author | "Thomas M."xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/author | "Bianchi M.W."xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/author | "Bianchi M.W."xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/author | "Guivarc'H D."xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/author | "Guivarc'H D."xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/name | "Mol. Gen. Genet."xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/name | "Mol. Gen. Genet."xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/pages | "337-345"xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/pages | "337-345"xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/title | "Arabidopsis homologs of the shaggy and GSK-3 protein kinases: molecular cloning and functional expression in Escherichia coli."xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/title | "Arabidopsis homologs of the shaggy and GSK-3 protein kinases: molecular cloning and functional expression in Escherichia coli."xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/volume | "242"xsd:string |
| http://purl.uniprot.org/citations/7509023 | http://purl.uniprot.org/core/volume | "242"xsd:string |