| http://purl.uniprot.org/citations/7510216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7510216 | http://www.w3.org/2000/01/rdf-schema#comment | "Stat91 (a 91 kd protein that acts as a signal transducer and activator of transcription) is inactive in the cytoplasm of untreated cells but is activated by phosphorylation on tyrosine in response to a number of polypeptide ligands, including interferon alpha (IFN-alpha) and IFN-gamma. We report here that the inactive Stat91 in the cytoplasm of untreated cells is a monomer and that upon IFN-gamma-induced phosphorylation it forms a stable homodimer. Only the dimer is capable of binding to a specific DNA sequence directing transcription. Through dissociation and reassociation assays, we show that dimerization of Stat91 is mediated through SH2-phosphotyrosyl peptide interactions. Dimerization involving SH2 recognition of specific phosphotyrosyl peptides may well provide a prototype for interactions among family members of STAT proteins to form different transcription complexes."xsd:string |
| http://purl.uniprot.org/citations/7510216 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(94)90357-3"xsd:string |
| http://purl.uniprot.org/citations/7510216 | http://purl.uniprot.org/core/author | "Darnell J.E. Jr."xsd:string |
| http://purl.uniprot.org/citations/7510216 | http://purl.uniprot.org/core/author | "Cowburn D."xsd:string |
| http://purl.uniprot.org/citations/7510216 | http://purl.uniprot.org/core/author | "Qureshi S.A."xsd:string |
| http://purl.uniprot.org/citations/7510216 | http://purl.uniprot.org/core/author | "Horvath C.M."xsd:string |
| http://purl.uniprot.org/citations/7510216 | http://purl.uniprot.org/core/author | "Huang L.H."xsd:string |
| http://purl.uniprot.org/citations/7510216 | http://purl.uniprot.org/core/author | "Shuai K."xsd:string |
| http://purl.uniprot.org/citations/7510216 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7510216 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/7510216 | http://purl.uniprot.org/core/pages | "821-828"xsd:string |
| http://purl.uniprot.org/citations/7510216 | http://purl.uniprot.org/core/title | "Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions."xsd:string |
| http://purl.uniprot.org/citations/7510216 | http://purl.uniprot.org/core/volume | "76"xsd:string |
| http://purl.uniprot.org/citations/7510216 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7510216 |
| http://purl.uniprot.org/citations/7510216 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7510216 |
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| http://purl.uniprot.org/uniprot/#_P01562-mappedCitation-7510216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7510216 |
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