| http://purl.uniprot.org/citations/7512959 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7512959 | http://www.w3.org/2000/01/rdf-schema#comment | "We are investigating the role of gamma-chain in functions mediated by the high affinity Fc receptor for IgG (Fc gamma RI). In a previous study, we found that gamma-chain, which is a member of the family of zeta-chain proteins, associates with Fc gamma RI. Here we show that clustering of Fc gamma RI leads to a rapid and transient tyrosine phosphorylation of gamma-chain in U937 cells. The response was limited to Fc gamma RI activation, and no phosphorylation of gamma-chain was observed after cross-linking of monoclonal antibodies to other surface receptors on these cells. The gamma-chain phosphorylated after Fc gamma RI clustering was the gamma-chain associated with the receptor. We also identified Syk as one of the kinases associated with the receptor complex. Upon Fc gamma RI activation, Syk, but not ZAP-70, was phosphorylated, and reimmunoadsorption experiments of phosphoproteins from immune complex in vitro kinase assays indicated that Syk is part of the activated gamma-chain-Fc gamma RI complex. These results suggest that gamma-chain links Fc gamma RI to intracellular transduction pathways."xsd:string |
| http://purl.uniprot.org/citations/7512959 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(17)32688-1"xsd:string |
| http://purl.uniprot.org/citations/7512959 | http://purl.uniprot.org/core/author | "Anderson C.L."xsd:string |
| http://purl.uniprot.org/citations/7512959 | http://purl.uniprot.org/core/author | "Duchemin A.M."xsd:string |
| http://purl.uniprot.org/citations/7512959 | http://purl.uniprot.org/core/author | "Ernst L.K."xsd:string |
| http://purl.uniprot.org/citations/7512959 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7512959 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/7512959 | http://purl.uniprot.org/core/pages | "12111-12117"xsd:string |
| http://purl.uniprot.org/citations/7512959 | http://purl.uniprot.org/core/title | "Clustering of the high affinity Fc receptor for immunoglobulin G (Fc gamma RI) results in phosphorylation of its associated gamma-chain."xsd:string |
| http://purl.uniprot.org/citations/7512959 | http://purl.uniprot.org/core/volume | "269"xsd:string |
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