| http://purl.uniprot.org/citations/7514679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7514679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7514679 | http://www.w3.org/2000/01/rdf-schema#comment | "The porcine group C rotavirus (Cowden strain) NSP3 protein (the group C equivalent of the group A gene 7 product, formerly called NS34) shares homology with known double-stranded RNA-binding proteins, such as the interferon-induced, double-stranded RNA-dependent protein kinase PKR. A clone of NSP3, expressed both in vitro and in COS-1 cells, led to the synthesis of minor amounts of a product with an M(r) of 45,000 (the expected full-length M(r) of NSP3) and major amounts of products with M(r)s of 38,000 and 8,000. Restriction enzyme digestion analysis prior to expression in vitro and amino-terminal sequence analysis suggest that the products with M(r)s of 38,000 and 8,000 are cleavage products of the protein with an M(r) of 45,000. The full-length protein and the product with an M(r) of 8,000, both of which contain the motif present in double-stranded RNA-binding proteins, bound specifically to double-stranded RNA. The products with M(r)s of 45,000 and 8,000 were also detected in Cowden strain-infected MA104 cells. NSP3 products expressed in COS-1 cells were capable of inhibiting activation of the double-stranded RNA-dependent protein kinase similar to other double-stranded RNA-binding proteins, and NSP3 products expressed in HeLa cells were capable of rescuing the replication of an interferon-sensitive deletion mutant of vaccinia virus."xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.68.6.3821-3829.1994"xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.68.6.3821-3829.1994"xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/author | "Jiang B."xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/author | "Jiang B."xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/author | "Jacobs B.L."xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/author | "Jacobs B.L."xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/author | "Langland J.O."xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/author | "Langland J.O."xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/author | "Pettiford S."xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/author | "Pettiford S."xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/pages | "3821-3829"xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/pages | "3821-3829"xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/title | "Products of the porcine group C rotavirus NSP3 gene bind specifically to double-stranded RNA and inhibit activation of the interferon-induced protein kinase PKR."xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/title | "Products of the porcine group C rotavirus NSP3 gene bind specifically to double-stranded RNA and inhibit activation of the interferon-induced protein kinase PKR."xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/7514679 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7514679 |
| http://purl.uniprot.org/citations/7514679 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7514679 |