| http://purl.uniprot.org/citations/7515500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7515500 | http://www.w3.org/2000/01/rdf-schema#comment | "The immunophilin-immunosuppressant complexes cyclophilin-cyclosporin A (CsA) and FKBP12-FK506 inhibit the phosphatase calcineurin to block T-cell activation. Although cyclophilin A, FKBP12, and calcineurin are highly conserved from yeast to man, none had previously been shown to be essential for viability. We find that CsA-sensitive yeast strains are FK506 hypersensitive and demonstrate that calcineurin is required for viability in these strains. Mutants lacking cyclophilin A or FKBP12 are resistant to CsA or FK506, respectively. Thus, both the immunosuppressive and the antifungal actions of CsA and FK506 result from calcineurin inhibition by immunophilin-drug complexes. In yeast strains in which calcineurin is not essential, calcineurin inhibition or mutation of calcineurin confers hypersensitivity to LiCl or NaCl, suggesting that calcineurin regulates cation transport."xsd:string |
| http://purl.uniprot.org/citations/7515500 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.91.12.5372"xsd:string |
| http://purl.uniprot.org/citations/7515500 | http://purl.uniprot.org/core/author | "Heitman J."xsd:string |
| http://purl.uniprot.org/citations/7515500 | http://purl.uniprot.org/core/author | "Cardenas M.E."xsd:string |
| http://purl.uniprot.org/citations/7515500 | http://purl.uniprot.org/core/author | "Movva N.R."xsd:string |
| http://purl.uniprot.org/citations/7515500 | http://purl.uniprot.org/core/author | "Hemenway C.S."xsd:string |
| http://purl.uniprot.org/citations/7515500 | http://purl.uniprot.org/core/author | "Breuder T."xsd:string |
| http://purl.uniprot.org/citations/7515500 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7515500 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/7515500 | http://purl.uniprot.org/core/pages | "5372-5376"xsd:string |
| http://purl.uniprot.org/citations/7515500 | http://purl.uniprot.org/core/title | "Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains."xsd:string |
| http://purl.uniprot.org/citations/7515500 | http://purl.uniprot.org/core/volume | "91"xsd:string |
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| http://purl.uniprot.org/uniprot/P14832 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/7515500 |
| http://purl.uniprot.org/uniprot/P23287 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/7515500 |
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| http://purl.uniprot.org/uniprot/P14747 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/7515500 |