| http://purl.uniprot.org/citations/7515715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7515715 | http://www.w3.org/2000/01/rdf-schema#comment | "The Wsh is a mutant allele at the W (c-kit) locus of mice, but no significant abnormalities are found at the coding region of the Wsh allele. Since cultured mast cells derived from the spleen of Wsh/Wsh mice do not express messenger RNA (mRNA) of c-kit, we studied the interrelation between the number of mast cells and the magnitude of c-kit mRNA expression in the skin of Wsh/Wsh mice of various ages. The number of mast cells in the skin of Wsh/Wsh embryos of 18 days postcoitum (pc) was approximately 40% that of normal control (+/+) embryos, but the number of mast cells decreased exponentially after birth; the number dropped to 0.6% that of +/+ mice at day 150 after birth. A weak but apparent signal of c-kit mRNA was detectable in the skin of 18-day pc Wsh/Wsh embryos by RNase protection assay but not in the skin of 5-day-old Wsh/Wsh mice. The number of c-kit protein-containing cells was significantly greater in the skin of 18-day pc Wsh/Wsh embryos than in the skin of 5-day-old Wsh/Wsh mice. The abolishment of c-kit mRNA expression appeared to be specific, because the expression of mast cell carboxypeptidase A mRNA but not of c-kit mRNA was detectable by in situ hybridization in skin mast cells of 5-day-old Wsh/Wsh mice. Taken together, the expression of c-kit mRNA was abolished first, then the content of c-kit protein dropped to undetectable levels, and then the disappearance of Wsh/Wsh mast cells themselves followed."xsd:string |
| http://purl.uniprot.org/citations/7515715 | http://purl.uniprot.org/core/author | "Kitamura Y."xsd:string |
| http://purl.uniprot.org/citations/7515715 | http://purl.uniprot.org/core/author | "Nomura S."xsd:string |
| http://purl.uniprot.org/citations/7515715 | http://purl.uniprot.org/core/author | "Yamazaki M."xsd:string |
| http://purl.uniprot.org/citations/7515715 | http://purl.uniprot.org/core/author | "Tsujimura T."xsd:string |
| http://purl.uniprot.org/citations/7515715 | http://purl.uniprot.org/core/author | "Morii E."xsd:string |
| http://purl.uniprot.org/citations/7515715 | http://purl.uniprot.org/core/author | "Isozaki K."xsd:string |
| http://purl.uniprot.org/citations/7515715 | http://purl.uniprot.org/core/author | "Onoue H."xsd:string |
| http://purl.uniprot.org/citations/7515715 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7515715 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/7515715 | http://purl.uniprot.org/core/pages | "3509-3516"xsd:string |
| http://purl.uniprot.org/citations/7515715 | http://purl.uniprot.org/core/title | "C-kit gene is expressed by skin mast cells in embryos but not in puppies of Wsh/Wsh mice: age-dependent abolishment of c-kit gene expression."xsd:string |
| http://purl.uniprot.org/citations/7515715 | http://purl.uniprot.org/core/volume | "83"xsd:string |
| http://purl.uniprot.org/citations/7515715 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7515715 |
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