http://purl.uniprot.org/citations/7516330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/7516330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/7516330 | http://www.w3.org/2000/01/rdf-schema#comment | "Binding of fibroblast growth factor (FGF) to the fibroblast growth factor receptor leads to autophosphorylation of the receptor on several tyrosine residues. Wild-type FGF receptor 1 (flg) and a mutated receptor (Y766F), in which an autophosphorylation site (Tyr-766) was mutated to phenylalanine, were expressed in rat myoblasts and in hematopoietic Ba/F3 cells. It was found that the point mutation at Tyr-766 resulted in a decrease in FGF receptor internalization, as well as a reduction in both ligand-induced FGF receptor down-regulation and degradation. It has been shown previously that phosphorylation of Tyr-766 is essential for interaction with phospholipase C gamma and that the Y766F FGF receptor mutant is unable to stimulate phosphatidylinositol hydrolysis and Ca2+ release from internal stores. The results presented in this report indicate that Tyr-766 is also essential for cellular trafficking of FGF receptor."xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(17)32519-x"xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(17)32519-x"xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/author | "Sorokin A."xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/author | "Sorokin A."xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/author | "Schlessinger J."xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/author | "Schlessinger J."xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/author | "Mohammadi M."xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/author | "Mohammadi M."xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/pages | "17056-17061"xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/pages | "17056-17061"xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/title | "Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766."xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/title | "Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766."xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/volume | "269"xsd:string |
http://purl.uniprot.org/citations/7516330 | http://purl.uniprot.org/core/volume | "269"xsd:string |
http://purl.uniprot.org/citations/7516330 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7516330 |
http://purl.uniprot.org/citations/7516330 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7516330 |